ArticleIranian journal of basic medical sciences2022
Lactoferrin mitigates ethanol-induced gastric ulcer via modulation of ROS/ICAM-1/Nrf2 signaling pathway in Wistar rats.
Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Protective and therapeutic roles of Phoenix dactylifera L. Zaghloul cultivar leaves extract against ethanol-induced gastric ulcer in rats.Journal of molecular histology · 2026Article
- Gastroprotective Effects of Green Synthesised Silver Nanoparticles Using Artocarpus Lakoocha Leaves Improves Oxidative Stress and Control Inflammation Modulating Via Inflammatory Markers in Ethanol Induced Ulcer Model in Mice.Biological trace element research · 2026Article
- Topical treatment of diabetic foot ulcers using a novel quercetin-loaded hyaluosome gel nanoformulation.Scientific reports · 2026Article
- Phyto-Mediated Zinc Oxide Nanoparticles fromLife (Basel, Switzerland) · 2025Article
- The Improvement of Experimentally Induced Gastric Ulcers in Rats by Inhibiting Vascularization Through the Blocking of the TNF-α Type 1 Receptor.Immunity, inflammation and disease · 2025Article
- Article
- Echinacea purpurea ameliorates Bleomycin-induced pulmonary fibrosis in rats through modulating NADPH oxidase-4 and endothelin-1/connective tissue growth factor/matrix metalloproteinases signalling axis.Scientific reports · 2025Article
- Histological study of the therapeutic effect of valerian extract alone or in combination with co-enzyme Q10 on experimentally induced gastric ulcers in adult albino rats: a light and scanning electron microscopic study.Journal of molecular histology · 2025Article
- Review
- β-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies.Inflammopharmacology · 2024Article
- Pylorus ligation-induced hyperacidity: synergistic prophylactic effects of linagliptin and L-arginine via up-regulation of EP4 receptor subtype and improvement of vascular endothelial damage.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Recommendations for nutritional supplements for dry eye disease: current advances.Frontiers in pharmacology · 2024Review
- A study of roflumilast treatment on functional and structural changes in hippocampus in depressed Adult male Wistar rats.PloS one · 2024Article
- Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway.Metabolic brain disease · 2023Article
- Antimicrobial Effects of Lactoferrin againstPathogens (Basel, Switzerland) · 2023Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: We aimed to investigate the gastroprotective effect of lactoferrin (LF; 100 & 300 mg/kg) in male Wistar rats Materials and Methods: Rats were randomly allocated into 4 groups: control, ethanol, ethanol+LF100, and ethanol+LF300. LF100 & 300 were given 15 days before ulcer induction. At the end of the experiment, the gastric mucosa was examined macroscopically and microscopically. Results: The ethanol group showed damage and degeneration of the stomach mucosa in addition to elevation of oxidative and inflammatory biomarkers. LF showed explicit healing of the gastric mucosal damage. LF reduced gastric malondialdehyde (MDA), tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), myeloperoxidase (MPO), and intracellular adhesion molecule-1 (ICAM-1). On the other hand, LF elevated the depleted reduced glutathione (GSH) and Nuclear factor-erythroid factor 2 (Nrf2). Conclusion: Our current study is the first to study the antiulcer effect of LF via its potential modulatory effects on the ROS/ICAM-1/Nrf2 signaling pathway. Moreover, we concluded that pretreatment with LF100 & 300 mitigated the ethanol-induced gastric ulcer via modulation of both oxidative stress and inflammatory responses.
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