ArticleFrontiers in endocrinology2022
Relationship of the metabolic score for insulin resistance and the risk of stroke in patients with hypertension: A cohort study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- The mediating role of inflammation and nutrition metabolism in the methylmalonic acid-stroke association.Clinics (Sao Paulo, Brazil) · 2026Article
- Nonlinear association between metabolic score for insulin resistance (METS-IR) and prevalent hypertension: a cross-sectional study.BMC cardiovascular disorders · 2026Article
- The role of visceral obesity surrogate markers in predicting cardiovascular disease: Insights from the CHARLS study.Medicine · 2026Article
- Assessment of seven insulin resistance surrogate indexes for predicting cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between METS-IR and incident stroke in a nationwide prospective cohort of non-diabetic Chinese adults.BMC neurology · 2026Article
- Association between the Metabolic Score for Visceral Fat (METS-VF) and incident hypertension in middle-aged and older Chinese adults: a nationwide prospective cohort study.BMC public health · 2026Article
- The Prognostic Value of Insulin Resistance Indices for Major Adverse Cardiovascular Events in Young and Middle-Aged Patients With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Beyond HOMA-IR: Comparative Evaluation of Insulin Resistance and Anthropometric Indices Across Prediabetes and Type 2 Diabetes Mellitus in Metabolic Syndrome Patients.Life (Basel, Switzerland) · 2025Article
- Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation.Aging clinical and experimental research · 2025Article
- Comparative analysis of insulin resistance indicators in predicting reversion from prediabetes to normoglycemia.Diabetology & metabolic syndrome · 2025Article
- Evaluation of four insulin resistance surrogate indicators for predicting short-term mortality in critically ill patients with ischemic stroke: a nationwide retrospective cohort study.Cardiovascular diabetology · 2025Article
- Association of metabolic score for insulin resistance and preeclampsia: a multicenter cohort study.Lipids in health and disease · 2025Article
- Cerebrovascular diseases in ADHD patients with metabolic comorbidities: a retrospective cohort study.BMC psychiatry · 2025Article
- Article
- Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005-2018: a cross-sectional study.BMC cancer · 2025Article
- Comparing the impact of cumulative insulin resistance surrogates exposure on stroke: optimizing prevention strategies.Lipids in health and disease · 2025Article
- Dietary live microorganisms and depression-driven mortality in hypertensive patients: NHANES 2005-2018.Journal of health, population, and nutrition · 2025Article
- Association between TG/HDL-C and hypertension in Chinese middle-aged and older adults: findings from CHARLS.BMC cardiovascular disorders · 2025Article
- Associations between triglyceride-glucose index combined with waist circumference and heart failure in individuals with different body mass indices: a cross-sectional study using NHANES 2011-2020 data.Lipids in health and disease · 2025Article
- Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China.Lipids in health and disease · 2025Article
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8 authors.
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Abstract
Background: The current status of the dose-response relationship between the metabolic score for insulin resistance (METS-IR) and new-onset stroke in hypertensive patients and its subtypes is unclear. This study aimed to determine the association between METS-IR and incident stroke and its subtypes within a cohort of Chinese hypertensive patients. Methods: A total of 14032 hospitalized patients with hypertension from January 1, 2010, to December 31, 2021, were included in this retrospective cohort study. Cox models and restricted cubic splines were applied to determine the association between METS-IR and the risk of stroke. Results: During a median follow-up of 4.80 years, 1067 incident stroke cases occurred. Patients in the highest quartile group of METS-IR levels exhibited a higher risk of stroke (HR, 1.80; 95% CI, 1.50-2.17) and ischemic stroke (HR, 1.96; 95% CI, 1.60-2.42) than those in the lowest quartile group. However, no significant associations were observed between METS-IR and the risk of hemorrhagic stroke. Restricted cubic spline analysis suggested a nearly J-shaped association between METS-IR and risk of stroke and ischemic stroke (P for nonlinearity < 0.001). METS-IR did produce a significant improvement in the C statistic when added to the basic model (from 0.637 to 0.664, P < 0.001). Notably, the addition of METS-IR to the basic model resulted in a significant improvement in predicting incident total stroke and ischemic stroke. Conclusions: This cohort study suggests a relationship between METS-IR and the risk of stroke and ischemic stroke. Further studies are required to elucidate the underlying mechanisms.
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