Evidence map›Paper›PMID 36545765›Full record

ArticlePsychological medicine2023

One versus two biological parents with mental disorders: Relationship to educational attainment in the next generation.

Anna Sidorchuk, Gustaf Brander, Ana Pérez-Vigil, James J Crowley, Henrik Larsson, Paul Lichtenstein, David Mataix-Cols, Ashley E Nordsletten

Open access · hybridAbstract read
In one paragraph

Article in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Anna SidorchukDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Gustaf BranderDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ana Pérez-VigilDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic de Barcelona, Barcelona, Spain.
James J CrowleyDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
David Mataix-ColsDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Ashley E NordslettenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-6037-5053
Karolinska Institutet · SEHospital Clínic de Barcelona · ESÖrebro University · SEUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USUppsala University · SE

Funding

OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment MechanismsR01MH110427 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2016 to 2021
$3.0M
Investigating the molecular mechanisms and consequences of assortative mating in major psychiatric disorders: completing a missing piece of the psychiatric genetics puzzleR21MH112963 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CROWLEY, JAMES JOSEPH · 2017 to 2018
$329k
Distilling the relationship of parental psychiatric illness to offspring productivity and social outcomes: evidence base for preventive strategiesR03HD109468 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NORDSLETTEN, ASHLEY · 2022 to 2023
$156k
NICHD NIH HHS R03 HD109468NIMH NIH HHS R01 MH110427NIMH NIH HHS R21 MH112963
6 · The paper itself

Abstract

backgroundBoth maternal and, separately, paternal mental illness are associated with diminished academic attainment among children. However, the differential impacts of diagnostic type and degree of parental burden (e.g. one v. both parents affected) on these functional outcomes are unknown.

methodsUsing the Swedish national patient (NPR) and multi-generation (MGR) registers, 2 226 451 children (1 290 157 parental pairs), born 1 January 1973-31 December 1997, were followed through 31 December 2013. Diagnostic status of all cohort members was defined for eleven psychiatric disorders, and families classed by exposure: (1) parents affected with any disorder, (2) parents affected with a disorder group (e.g. neuropsychiatric disorders), and (3) parents affected with a specific disorder (e.g. ADHD). Pairs were further defined as 'unaffected,' 'single-affected,', or 'dual-affected.' Among offspring, the study evaluated fulfillment of four academic milestones, from compulsory (primary) school through University (college). Sensitivity analyses considered the impact of child's own mental health, as well as parental education, on main effects.

resultsMarked reductions in the odds of achievement were observed, emerging at the earliest levels of schooling for both single-affected [adjusted odds ratio (aOR), 0.50; 95% CI 0.49-0.51] and dual-affected (aOR 0.29, 95% CI 0.28-0.30) pairs and persisting thereafter [aOR range (single), 0.52-0.65; aOR range (dual), 0.30-0.40]. This pattern was repeated for analyses within diagnosis/diagnostic group. Main results were robust to adjustment for offspring mental health and parent education level.

conclusionsParental mental illness is associated with profound reductions in educational attainment in the subsequent generation, with children from dual-affected families at uniquely high risk.

Indexed as

Mental DisordersChildEducational StatusFathersHumansMaleMental HealthParentsAnxietyassortative matingAutismdepressioneducational attainmentintergenerationalnon-random matingOCDpsychopathologyschizophreniasubstance use

Identifiers

PMID36545765
PMCPMC10719631
OpenAlexW4312094456

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.