Evidence map›Paper›PMID 36546321›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Human Macrophage Long Intergenic Noncoding RNA,

Esther Cynn, Daniel Y Li, Marcella E O'Reilly, Ying Wang, Alexander C Bashore, Anjali Jha, Andrea S Foulkes, Hanrui Zhang, Hanna Winter, Lars Maegdefessel and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Esther CynnCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).
Daniel Y LiMission Bio, South San Francisco, CA (D.Y.L.).
Marcella E O'ReillyCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).
Ying WangLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY (Y.W.).
Alexander C BashoreCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).
Anjali JhaBiostatistics Center, Massachusetts General Hospital, Boston (A.J., A.S.F.).
Andrea S FoulkesBiostatistics Center, Massachusetts General Hospital, Boston (A.J., A.S.F.).ORCID 0000-0002-9520-0501
Hanrui ZhangCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).ORCID 0000-0001-8655-938X
Hanna WinterDepartment of Vascular and Endovascular Surgery, Technical University Munich, Germany (H.W., L.M.).ORCID 0000-0001-8110-8627
Lars MaegdefesselDepartment of Vascular and Endovascular Surgery, Technical University Munich, Germany (H.W., L.M.).ORCID 0000-0001-5228-2634
Hanying YanDepartment of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia (H.Y., M.L.).ORCID 0000-0002-9227-1742
Mingyao LiDepartment of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia (H.Y., M.L.).
Leila RossCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).
Chenyi XueCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).
Muredach P ReillyCardiology Division, Department of Medicine, Columbia University Irving Medical Center, New York, NY (E.C., M.E.O., A.C.B., H.Z., L.R., C.X., M.P.R.).ORCID 0000-0002-3035-9386
Columbia University Irving Medical Center · USHarvard University · USUniversity of Pennsylvania · USGerman Centre for Cardiovascular Research · DEKarolinska Institutet · SEMission Bio (United States) · USRockefeller University · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Elucidation of Tissue-Specific Transcriptomic Profiles in Cardiometabolic DiseaseR01HL113147 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LI, MINGYAO, REILLY, MUREDACH P · 2012 to 2022
$6.8M
Discovering Wdfy3 as a novel regulator of macrophage efferocytosis by genome-wide CRISPR screenR01HL151611 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHANG, HANRUI · 2020 to 2024
$3.0M
Human LincRNAs in Macrophage Biology and Related Cardiometabolic DiseasesR01HL132561 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2017 to 2020
$2.8M
Computational and functional strategies to decipher lncRNAs in human atherosclerosisR01HL150359 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LI, MINGYAO, REILLY, MUREDACH P · 2020 to 2023
$2.7M
Methods for integrated analysis of multi-level omics dataR01GM127862 · NIGMS · MOUNT HOLYOKE COLLEGE · PI FOULKES, ANDREA S · 2018 to 2022
$1.7M
Macrophage-specific function of GWAS CAD-associated LIPA alleles in atherosclerosisR00HL130574 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZHANG, HANRUI · 2018 to 2020
$733k
NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696NHLBI NIH HHS R00 HL130574NHLBI NIH HHS R01 HL113147NHLBI NIH HHS R01 HL132561NHLBI NIH HHS R01 HL150359NHLBI NIH HHS R01 HL151611NIGMS NIH HHS R01 GM127862
6 · The paper itself

Abstract

backgroundLong noncoding RNAs (lncRNAs) have emerged as novel regulators of macrophage biology and inflammatory cardiovascular diseases. However, studies focused on lncRNAs in human macrophage subtypes, particularly human lncRNAs that are not conserved in rodents, are limited.

methodsThrough RNA-sequencing of human monocyte-derived macrophages, we identified suppressor of inflammatory macrophage apoptosis lncRNA (

resultsRNA-sequencing of human monocyte-derived macrophages identified

conclusions

Indexed as

AtherosclerosisPlaque, AtheroscleroticRNA, Long NoncodingApoptosisHEK293 CellsHumansHypoxia-Inducible Factor 1LipopolysaccharidesMacrophagesNetrin-1Hypoxia-Inducible Factor 1LipopolysaccharidesNetrin-1NTN1 protein, humanRNA, Long Noncodingapoptosisatherosclerosiscardiovascular diseasemacrophageRNA, long noncoding

Identifiers

PMID36546321
PMCPMC10162399
OpenAlexW4312075222

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.