Evidence map›Paper›PMID 36548656›Full record

ArticleTropical medicine and infectious disease2022

Nano-Encapsulated Melatonin: A Promising Mucosal Adjuvant in Intranasal Immunization against Chronic Experimental

Doaa E Said, Eglal I Amer, Eman Sheta, Shaimaa Makled, Hala E Diab, Fadwa M Arafa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Advances and Translational Challenges inVeterinary sciences · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Doaa E SaidDepartment of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria 5424041, Egypt.
Eglal I AmerDepartment of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria 5424041, Egypt.
Eman ShetaDepartment of Pathology, Faculty of Medicine, Alexandria University, Alexandria 5424041, Egypt.ORCID 0000-0001-9018-5229
Shaimaa MakledDepartment of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.
Hala E DiabDepartment of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria 5424041, Egypt.
Fadwa M ArafaDepartment of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria 5424041, Egypt.ORCID 0000-0002-7753-3193
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin (MLT) is now emerging as one of the universally accepted immunostimulators with broad applications in medicine. It is a biological manipulator of the immune system, including mucosal ones. MLT was encapsulated in solid lipid nanoparticles (SLNs), then 100 mg/kg/dose of MLT-SLNs was used as an adjuvant of

Indexed as

antioxidantIg Aimmunizationintranasalmelatoninoxidative stressToxoplasma gondii

Identifiers

PMID36548656
PMCPMC9785012
OpenAlexW4310035783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.