Evidence map›Paper›PMID 36551866›Full record

ArticleBiomedicines2022

Exosomes from the Uterine Cavity Mediate Immune Dysregulation via Inhibiting the JNK Signal Pathway in Endometriosis.

Ying Jiang, Xiaoshan Chai, Shengnan Chen, Zhaoying Chen, Hao Tian, Min Liu, Xianqing Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. The role of small extracellular vesicle-miRNAs in endometriosis.Human reproduction (Oxford, England) · 2023
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying JiangDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Xiaoshan ChaiDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Shengnan ChenDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Zhaoying ChenDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Hao TianDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Min LiuDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Xianqing WuDepartment of Obstetrics and Gynecology, The Second Xiangya Hospital of Central South University, Changsha 430011, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

Fundamental Research Funds for the Central Universities of Central South University 2022ZZTS0828National Natural Science Foundation of China 81873826
6 · The paper itself

Abstract

Endometriosis is a chronic inflammatory disease with an uncertain pathogenesis. Peritoneal immune dysregulation plays an important role in the pathogenesis of endometriosis. Exosomes are messengers of intercellular communication. This study mainly investigated the role of exosomes from the uterine cavity in endometriosis. Exosomes of the uterine aspirate fluid were isolated and cocultured with macrophages for 48 h. Flow cytometry was used to detect macrophage polarization. A Human MAPK Phosphorylation Antibody Array and Western blot were used to detect the phosphorylation of the MAPK pathway. A microRNA sequencing analysis was used to detect differentially expressed miRNAs. Our research found that exosomes of the uterine aspirate fluid from endometriosis could reduce the proportion of CD80

Indexed as

endometriosisexosomesimmune dysregulationmacrophages polarizationmicroRNAsuterine aspirate fluid

Identifiers

PMID36551866
PMCPMC9775046
OpenAlexW4310610841

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.