Evidence map›Paper›PMID 36554625›Full record

ArticleInternational journal of environmental research and public health2022

1000 Days: The "WeCare Generation" Program-The Ultimate Model for Improving Human Mental Health and Economics: The Study Protocol.

Orlando Uccellini, Andrea Benlodi, Emanuele Caroppo, Loredana Cena, Gianluca Esposito, Isabel Fernandez, Maria Ghazanfar, Antonio Imbasciati, Francesco Longo, Marianna Mazza and 7 more

Abstract readClinical Trial Protocol
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Orlando UccelliniDepartment of Mental Health, ASST Brianza, 20871 Vimercate, Italy.
Andrea BenlodiClinical Psychology Unit Carlo Poma Hospital, ASST Mantova, 46100 Mantua, Italy.
Emanuele CaroppoDepartment of Mental Health, Local Health Authority Roma 2, 00159 Rome, Italy.ORCID 0000-0001-9602-8208
Loredana CenaDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-3162-9237
Gianluca EspositoDepartment of Psychology and Cognitive Science, University of Trento, 38122 Trent, Italy.ORCID 0000-0002-9442-0254
Isabel FernandezEMDR Italia Association, 20814 Varedo, Italy.
Maria GhazanfarMaternal and Child Department, ASST Brianza, 20871 Vimercate, Italy.
Antonio ImbasciatiDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
Francesco LongoCergas Center for Research on Health and Social Care Management, SDA Bocconi University, 20136 Milan, Italy.
Marianna MazzaDepartment of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universita' Cattolica del Sacro Cuore, 00168 Rome, Italy.ORCID 0000-0002-3007-8162
Giuseppe MaranoDepartment of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry and Psychology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universita' Cattolica del Sacro Cuore, 00168 Rome, Italy.
Renata NacinovichChild and Adolescent Neuropsichiatry, ASST Monza, NeuroMI-Milan Center for Neuroscience, University of Milano Bicocca, 20126 Milan, Italy.ORCID 0000-0002-3832-2860
Antonio PignattoDepartment of Psychology, IUSTO-Salesian University Institute Torino Rebaudengo, 10155 Turin, Italy.ORCID 0000-0002-6465-2716
Arthur RolnickDepartment of Economics, Humphrey School of Public Affairs, University of Minnesota, Minneapolis, MN 55455, USA.
Marco TrivelliGeneral and Economic Direction, ASST Brianza, 20871 Vimercate, Italy.
Elena SpadaMagistica, 23875 Lecco, Italy.
Cinzia VanziniTraining Sector Management, ASST Brianza, 20871 Vimercate, Italy.ORCID 0000-0003-4045-6128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe COVID-19 pandemic stressed the necessity of a new resilience of the human population and health system. The "WeCare Generation" program is a new proposal of territorial intervention, with a new paradigm, on the diseases of the human body and mind.

backgroundIn recent decades, the independent strands of investigation on brain plasticity and early trauma consequences have demonstrated that traumatic experiences in the period from pregnancy to the age of 3 years have an enormous impact on an individual's future development, and both physical and mental health. Research shows that adverse child experiences (ACEs) are associated with a strong risk of conditions such as: harmful alcohol use, smoking, illicit drug use, high body-mass index, depression, anxiety, interpersonal violence, cancer, type 2 diabetes, cardiovascular diseases, stroke respiratory diseases and, as a consequence, to a high financial cost in Italy and also across Europe (1-9% GDP) and the USA (total annual costs estimated to be USD 581 billion in Europe and USD 748 billion in North America). All this suggests that an early intervention on that traumatized-slice of population leads to multiplied savings.

methodsA multi-center, randomized, controlled trial was designed. The parents of the future neonatal population (from pregnancy to delivery) with trauma will be enrolled, and randomized to treatment, or control arm. The article describes in detail how the primary outpoint (cost to the national health system), and some secondary outpoints, will be collected. DISCUSSION: An overall rate of return on investment (ROI) statistically significant 13.0% per annum with an associated benefit/cost ratio (BCR) of 6.3 is expected as the primary outcome of the "WeCare Generation" program. Our proposed model predicts a new medical paradigm aiming to empower new generations, with a strong return on economy and health.

Indexed as

COVID-19Diabetes Mellitus, Type 2ChildChild, PreschoolEuropeFemaleHumansInfant, NewbornMental HealthMulticenter Studies as TopicPandemicsPregnancyRandomized Controlled Trials as Topicadverse childhood experienceschildeconomicgross domestic productparental traumapregnancypreventiontraumawelfare

Identifiers

PMID36554625
PMCPMC9779238

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.