Evidence map›Paper›PMID 36555652›Full record

ArticleInternational journal of molecular sciences2022

Identification of Darunavir Derivatives for Inhibition of SARS-CoV-2 3CL

Ling Ma, Yongli Xie, Mei Zhu, Dongrong Yi, Jianyuan Zhao, Saisai Guo, Yongxin Zhang, Jing Wang, Quanjie Li, Yucheng Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Computational andFrontiers in pharmacology · 2025
    Article
  3. Review
  4. Article
  5. Progress of Section "Biochemistry" in 2022.International journal of molecular sciences · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ling MaInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Yongli XieInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Mei ZhuInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Dongrong YiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Jianyuan ZhaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Saisai GuoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Yongxin ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Jing WangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Quanjie LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.ORCID 0000-0002-4151-0627
Yucheng WangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.
Shan CenInstitute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China.ORCID 0000-0003-3358-0411
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effective antiviral agents that treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed around the world. The 3C-like protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesDarunavirProtease InhibitorsSARS-CoV-2COVID-19HumansMolecular Docking Simulation3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesDarunavirProtease Inhibitors3CLproanti-coronavirus drugproteasescreening assaysevere acute respiratory syndrome coronavirus 2

Identifiers

PMID36555652
PMCPMC9781983
OpenAlexW4312195994

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.