Evidence map›Paper›PMID 36555708›Full record

ArticleInternational journal of molecular sciences2022

Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca

Frank Helle, Michael Hultström, Panagiotis Kavvadas, Bjarne Iversen, Christos E Chadjichristos, Christos Chatziantoniou

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Frank HelleINSERM UMR S 1155, Hôpital Tenon, 75020 Paris, France.ORCID 0000-0002-9650-2747
Michael HultströmRenal Research Group, Institute of Medicine, University of Bergen, 5007 Bergen, Norway.ORCID 0000-0003-4675-1099
Panagiotis KavvadasINSERM UMR S 1155, Hôpital Tenon, 75020 Paris, France.
Bjarne IversenRenal Research Group, Institute of Medicine, University of Bergen, 5007 Bergen, Norway.
Christos E ChadjichristosINSERM UMR S 1155, Hôpital Tenon, 75020 Paris, France.ORCID 0000-0001-6657-7900
Christos ChatziantoniouINSERM UMR S 1155, Hôpital Tenon, 75020 Paris, France.
Inserm · FRHaukeland University Hospital · NOUppsala University · SE

Funding

Inserm recurring annual fundingSorbonne University recurring annual fundingWestern Norway Regional Health Authority Annual fund
6 · The paper itself

Abstract

Notch3 plays an important role in the differentiation and development of vascular smooth muscle cells. Mice lacking Notch3 show deficient renal autoregulation. The aim of the study was to investigate the mechanisms involved in the Notch3-mediated control of renal vascular response. To this end, renal resistance vessels (afferent arterioles) were isolated from Notch3

Indexed as

KidneyNifedipineReceptor, Notch3Angiotensin IIAnimalsArteriolesCalciumCalcium Channel BlockersGene DeletionMibefradilMiceMice, KnockoutVascular ResistanceAngiotensin IICalciumCalcium Channel BlockersMibefradilNifedipineNotch3 protein, mouseReceptor, Notch3Ca2+ mobilizationNotch3renal haemodynamicsrenal resistance vesselsvasoreactivity

Identifiers

PMID36555708
PMCPMC9788231
OpenAlexW4312210667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.