Evidence map›Paper›PMID 36555774›Full record

ReviewInternational journal of molecular sciences2022

Reviewing the Potential Therapeutic Approaches Targeting the Modulation of Gastrointestinal Microflora in Schizophrenia.

Ilinca-Bianca Nita, Ovidiu-Dumitru Ilie, Alin Ciobica, Luminita-Diana Hritcu, Irina Dobrin, Bogdan Doroftei, Romeo Dobrin

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ilinca-Bianca NitaDepartment of Medicine III, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.
Ovidiu-Dumitru IlieDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University, Carol I Avenue, no 20A, 700505 Iasi, Romania.ORCID 0000-0002-4023-1765
Alin CiobicaDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University, Carol I Avenue, no 20A, 700505 Iasi, Romania.
Luminita-Diana HritcuInternal Medicine Clinic, Faculty of Veterinary Medicine, University of Life Sciences "Ion Ionescu de la Brad", Mihail Sadoveanu Street, no 3, 700490 Iasi, Romania.
Irina DobrinDepartment of Medicine III, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.
Bogdan DorofteiDepartment of Medicine VIII, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.ORCID 0000-0002-6618-141X
Romeo DobrinDepartment of Medicine III, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.ORCID 0000-0003-3023-0205
Grigore T. Popa University of Medicine and Pharmacy · ROAlexandru Ioan Cuza University · RO"Ion Ionescu de la Brad" Iasi University of Life Sciences · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia (SCZ) is a severe brain disorder characterized by an intriguing clinical panel that has begun to gain interest due to its particular phenotype. Having considered the role of gut microflora in psychiatry, the latest discoveries might offer further insight into the underlying mechanisms. Thus, we aimed to offer an updated overview of the therapeutic potential of microorganism-derived supplements alongside dedicated protocols that target the re-establishment of the host's eubiosis. Based on combinations of specific keywords, we performed searches in four databases (PubMed/Medline, ISI Web of Knowledge, Scopus, and ScienceDirect) for the established interval (2018-2022) and identified twenty two eligible cases, restricted only to human patients' experiences. Up until the writing of this manuscript, it has been revealed that the administration of specific lactic acid bacteria strains (

Indexed as

Antipsychotic AgentsClozapineGastrointestinal MicrobiomeProbioticsSchizophreniaHumansOlanzapinePrebioticsAntipsychotic AgentsClozapineOlanzapinePrebioticsfecal microbiota transplantationgut microfloramicrobial transfer therapyprebioticsprobioticsschizophreniasynbiotics

Identifiers

PMID36555774
PMCPMC9784651
OpenAlexW4312210500

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.