Understanding the Dynamics of the Structural States of Cannabinoid Receptors and the Role of Different Modulators.

Anjela Manandhar, Mona H Haron, Michael L Klein, Khaled Elokely

Open access · goldAbstract read

In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 36% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Differential Regulatory Effects of Cannabinoids and Vitamin E Analogs on Cellular Lipid Homeostasis and Inflammation in Human Macrophages.Antioxidants (Basel, Switzerland) · 2026
Article
Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1.Pharmaceuticals (Basel, Switzerland) · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anjela ManandharInstitute for Computational Molecular Science and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.

Mona H HaronNational Center for Natural Products Research, University of Mississippi, Oxford, MS 38677, USA.

Michael L KleinInstitute for Computational Molecular Science and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.

Khaled ElokelyInstitute for Computational Molecular Science and Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-2394-021X

Temple University · USUniversity of Mississippi · US

Funding

Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI WILLETT, KRISTINE L · 2018 to 2022

$5.3M

National Science Foundation CNS-1625061NIGMS NIH HHS P30 GM122733NIH HHS P30GM122733-01AUnited States Army Research Laboratory W911NF-16-2-0189

6 · The paper itself

Abstract

The cannabinoid receptors CB

Indexed as

cannabinoid receptorsionic lockrotameric toggle switchTHCVitamin E

Identifiers

PMID36556502

DOI10.3390/life12122137

PMCPMC9786085

OpenAlexW4312212018

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.