Evidence map›Paper›PMID 36557272›Full record

ArticleMetabolites2022

Plasma Prostaglandin E

Rachel J Fenske, Alicia M Weeks, Michael Daniels, Randall Nall, Samantha Pabich, Allison L Brill, Darby C Peter, Margaret Punt, Elizabeth D Cox, Dawn Belt Davis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Observational
  7. Metabolic Health and Disease: A Role of Osteokines?Calcified tissue international · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rachel J FenskeResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.ORCID 0000-0002-5417-0780
Alicia M WeeksResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
Michael DanielsResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
Randall NallResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
Samantha PabichDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3169-8942
Allison L BrillResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
Darby C PeterResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
Margaret PuntDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53706, USA.
Elizabeth D CoxDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Dawn Belt DavisResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.ORCID 0000-0002-0239-4715
Michelle E KimpleResearch Service, William S. Middleton Memorial VA Hospital, Madison, WI 53705, USA.
University of Wisconsin–Madison · US

Funding

The role of GLP-1 and CCK in the pancreatic islet to promote beta-cell survivalR01DK110324 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIS, DAWN B · 2016 to 2020
$2.0M
Molecular Mechanisms of Dysfunctional Prostaglandin Signaling in the Beta-CellR01DK102598 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI KIMPLE, MICHELLE E · 2014 to 2018
$1.7M
Role of inhibitory G protein signaling in regulating beta-cell function and survival in the type 1 diabetic stateF31DK109698 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI FENSKE, RACHEL J · 2017 to 2018
$87k
Transcriptional Regulation of Pancreatic Beta Cell MassI01BX001880 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DAVIS, DAWN B · 2013 to 2016
–
G Protein Mediated Mechanisms of Beta Cell Death Dysfunction and Decompensation in DiabetesI01BX003700 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI KIMPLE, MICHELLE E · 2018 to 2021
–
Functional studies of the novel diabetes gene TCF19I01BX004715 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DAVIS, DAWN B · 2019 to 2023
–
BLRD VA I01 BX001880BLRD VA I01 BX003700BLRD VA I01 BX004715BLRD VA I01 BX005804NIDDK NIH HHS F31 DK109698NIDDK NIH HHS R01 DK102598NIDDK NIH HHS R01 DK110324NIH HHS F31 DK109698NIH HHS R01 DK102598NIH HHS R01 DK110324
6 · The paper itself

Abstract

Over half of patients with type 2 diabetes (T2D) are unable to achieve blood glucose targets despite therapeutic compliance, significantly increasing their risk of long-term complications. Discovering ways to identify and properly treat these individuals is a critical problem in the field. The arachidonic acid metabolite, prostaglandin E

Indexed as

biomarkerclinical studydiabetes controlHbA1cinflammationplasma metabolitesprostaglandin E2type 2 diabetes

Identifiers

PMID36557272
PMCPMC9783643
OpenAlexW4311959759

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.