Evidence map›Paper›PMID 36558403›Full record

Trial reportNutrients2022

Effects of Carbohydrate Restriction on Body Weight and Glycemic Control in Individuals with Type 2 Diabetes: A Randomized Controlled Trial of Efficacy in Real-Life Settings.

Philip Weber, Mads N Thomsen, Mads Juul Skytte, Amirsalar Samkani, Martin Hansen Carl, Arne Astrup, Jan Frystyk, Jens J Holst, Bolette Hartmann, Sten Madsbad and 3 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Philip WeberDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
Mads N ThomsenDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
Mads Juul SkytteDepartment of Forensic Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0001-6607-2064
Amirsalar SamkaniDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.ORCID 0000-0002-2742-3893
Martin Hansen CarlDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
Arne AstrupDepartment of Obesity and Nutritional Sciences, Novo Nordisk Foundation, 2900 Hellerup, Denmark.ORCID 0000-0001-8968-8996
Jan FrystykDepartment of Clinical Medicine, Aarhus University, 8200 Aarhus, Denmark.
Jens J HolstNNF Centre for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-6853-3805
Bolette HartmannNNF Centre for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0001-8509-2036
Sten MadsbadDepartment of Endocrinology, Copenhagen University Hospital Amager Hvidovre, 2650 Hvidovre, Denmark.ORCID 0000-0002-5017-1815
Faidon MagkosDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 2200 Copenhagen, Denmark.ORCID 0000-0002-1312-7364
Thure KrarupDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.
Steen B HaugaardDepartment of Endocrinology, Copenhagen University Hospital Bispebjerg, 2400 Copenhagen, Denmark.ORCID 0000-0002-6827-7036
University of Copenhagen · DKBispebjerg Hospital · DKAarhus University · DKHvidovre Hospital · DKNovo Nordisk Foundation · DK

Funding

Arla Foods amba n/aThe Danish Dairy Research Foundation n/aThe Novo Nordisk Foundation and Copenhagen University Hospital Bispebjerg Frederiksberg n/a
6 · The paper itself

Abstract

A fully provided, hypocaloric, carbohydrate-reduced high-protein (CRHP) diet compared to a hypocaloric conventional diabetes (CD) diet for 6 weeks improved glycemic control to a greater extent in face of an intended 6% weight loss in individuals with type 2 diabetes mellitus (T2DM). The present 24-week extension of that study reports on the efficacy of CRHP and CD diets in a real-life setting. Sixty-five individuals with T2DM who completed the initial 6-week fully provided diet period (% energy from carbohydrate, protein, and fat was 30/30/40 in CRHP, and 50/17/33 in CD) continued a free-living, dietician guided 24-week period of which 59 individuals completed. The CRHP compared to CD group reported a 4% lower carbohydrate intake and had higher urea excretion by 22% (both

Indexed as

Diabetes Mellitus, Type 2Blood GlucoseBody WeightGlycated HemoglobinGlycemic ControlHumansWeight LossBlood GlucoseGlycated Hemoglobincarbohydrate restrictionglucose metabolismlipid metabolismmacronutrientstype 2 diabetes

Identifiers

PMID36558403
PMCPMC9788105
OpenAlexW4311970555

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.