Evidence map›Paper›PMID 36560541›Full record

ArticleVaccines2022

Sero-Epidemiological Study of

Tiziana Grassi, Francesco Bagordo, Marta Savio, Maria Cristina Rota, Francesco Vitale, Antonella Arghittu, Laura Sticchi, Giovanni Gabutti, On Behalf Of The Sero-Epidemiological Study Group

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
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  7. Article
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  9. Article
  10. Assessment of Pertussis Underreporting in Italy.Journal of clinical medicine · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Tiziana GrassiDepartment of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.ORCID 0000-0003-1200-2778
Francesco BagordoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari, 70121 Bari, Italy.ORCID 0000-0001-5208-5382
Marta SavioPost-Graduate School of Hygiene and Preventive Medicine, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-3404-8013
Maria Cristina RotaDepartment of Infectious Diseases, Italian Institute of Health (ISS), 00161 Roma, Italy.ORCID 0000-0002-9861-446X
Francesco VitaleDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
Antonella ArghittuDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-9257-1422
Laura SticchiDepartment of Health Sciences, University of Genova, 16132 Genova, Italy.
Giovanni GabuttiNational Coordinator of the Working Group "Vaccines and Immunization Policies", Italian Society of Hygiene, Preventive Medicine and Public Health, 16030 Cogorno, Italy.ORCID 0000-0002-7259-4923
On Behalf Of The Sero-Epidemiological Study Group
University of Bari Aldo Moro · ITUniversity of Ferrara · ITUniversity of Genoa · ITUniversity of Palermo · ITUniversity of Salento · ITUniversity of Sassari · IT

Funding

GlaxoSmithKline Biologicals SA Not applicable
6 · The paper itself

Abstract

A multicenter study was conducted to estimate the prevalence of pertussis IgG antibodies (anti-PTx) in the Italian population. Serum samples (4154) collected in the years 2019−2020 from subjects aged 6 to 90 years were tested. The anti-PTx IgG levels were determined by ELISA test. The limit of detection was 5 IU/mL (International Units per milliliter); values ≥ 40 IU/mL and ≥100 IU/mL indicate an infection that has occurred in recent years and a recent infection (occurred during the last year), respectively. The mean concentration of anti-PTx IgG antibodies in the tested samples was 13 IU/mL; 1.0% of subjects had a titer ≥ 100 IU/mL, 5.3% a titer between 40 and 100 IU/mL, and 38.9% a titer < 5 IU/mL. The mean antibody concentration was significantly higher in males than in females. The age group 25−39 years had the lowest percentage of negative subjects (36.9%) and the highest prevalence of subjects with antibody titers ≥ 100 IU/mL (1.3%). In the age group ≥ 65 years, the prevalence of subjects with titers between 40 and 100 IU/mL (6.7%) and the percentage of negative subjects (44.8%) was higher than in the other age groups. The results highlight the possible role of adolescents and adults in the transmission of B. pertussis.

Indexed as

general populationItalypertussissero-epidemiology

Identifiers

PMID36560541
PMCPMC9782223
OpenAlexW4311376288

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.