Evidence map›Paper›PMID 36560741›Full record

ArticleViruses2022

Severity of COVID-19 among Hospitalized Patients: Omicron Remains a Severe Threat for Immunocompromised Hosts.

Louis Nevejan, Sien Ombelet, Lies Laenen, Els Keyaerts, Thomas Demuyser, Lucie Seyler, Oriane Soetens, Els Van Nedervelde, Reinout Naesens, Dieter Geysels and 16 more

Abstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. AnPathogens (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Louis NevejanDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-8306-4023
Sien OmbeletDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Lies LaenenDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-9118-8608
Els KeyaertsKU Leuven Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical Microbiology, 3000 Leuven, Belgium.
Thomas DemuyserDepartment of Microbiology and Infection Control, Vrije Universiteit Brussel (VUB), UZ Brussel-University Hospitals Brussels, 1090 Brussels, Belgium.ORCID 0000-0002-6410-9246
Lucie SeylerDepartment of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), UZ Brussel-University Hospitals Brussels, 1090 Brussels, Belgium.
Oriane SoetensDepartment of Microbiology and Infection Control, Vrije Universiteit Brussel (VUB), UZ Brussel-University Hospitals Brussels, 1090 Brussels, Belgium.ORCID 0000-0002-4281-9749
Els Van NederveldeDepartment of Internal Medicine and Infectious Diseases, Vrije Universiteit Brussel (VUB), UZ Brussel-University Hospitals Brussels, 1090 Brussels, Belgium.ORCID 0000-0002-3836-0517
Reinout NaesensDepartment of Medical Microbiology, Department of infection prevention and control, ZNA Middelheim, 2020 Antwerp, Belgium.ORCID 0000-0003-1004-7737
Dieter GeyselsDepartment of Medical Microbiology, Department of infection prevention and control, ZNA Middelheim, 2020 Antwerp, Belgium.
Walter VerstrepenDepartment of Medical Microbiology, Department of infection prevention and control, ZNA Middelheim, 2020 Antwerp, Belgium.
Lien CattoirClinical Laboratory of Microbiology, OLV Hospital, 9300 Aalst, Belgium.
Steven MartensClinical Laboratory of Microbiology, OLV Hospital, 9300 Aalst, Belgium.
Charlotte MichelDepartment of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Université Libre de Bruxelles, 1000 Brussels, Belgium.ORCID 0000-0003-0250-2664
Elise MathieuDepartment of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Marijke ReyndersDepartment of Laboratory Medicine-Medical Microbiology, AZ Sint Jan Brugge-Oostende, 8000 Brugge, Belgium.ORCID 0000-0003-2079-1279
Anton EvenepoelDepartment of Laboratory Medicine-Medical Microbiology, AZ Sint Jan Brugge-Oostende, 8000 Brugge, Belgium.
Jorn HellemansDepartment of Laboratory Medicine-Medical Microbiology, AZ Sint Jan Brugge-Oostende, 8000 Brugge, Belgium.ORCID 0000-0002-4424-3157
Merijn VanheeDepartment of Laboratory Medicine-Medical Microbiology, AZ Sint Jan Brugge-Oostende, 8000 Brugge, Belgium.
Koen MagermanClinical Laboratory, Jessa Hospital, 3500 Hasselt, Belgium.
Justine MaesClinical Laboratory, Jessa Hospital, 3500 Hasselt, Belgium.
Veerle MatheeussenDepartment of Microbiology, University Hospital Antwerp, 2650 Antwerp, Belgium.ORCID 0000-0003-2137-2068
Hélène BoogaertsDepartment of Microbiology, University Hospital Antwerp, 2650 Antwerp, Belgium.
Katrien LagrouDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-8668-1350
Lize CuypersDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0002-9433-8752
Emmanuel AndréDepartment of Laboratory Medicine, National Reference Center for Respiratory Pathogens, UZ Leuven-University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.ORCID 0000-0001-8321-3770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the general population in the context of a relatively high immunity gained through the early waves of coronavirus disease 19 (COVID-19), and vaccination campaigns. Despite this context, a significant number of patients were hospitalized, and identifying the risk factors associated with severe disease in the Omicron era is critical for targeting further preventive, and curative interventions. We retrospectively analyzed the individual medical records of 1501 SARS-CoV-2 positive hospitalized patients between 13 December 2021, and 13 February 2022, in Belgium, of which 187 (12.5%) were infected with Delta, and 1036 (69.0%) with Omicron. Unvaccinated adults showed an increased risk of moderate/severe/critical/fatal COVID-19 (crude OR 1.54; 95% CI 1.09-2.16) compared to vaccinated patients, whether infected with Omicron or Delta. In adults infected with Omicron and moderate/severe/critical/fatal COVID-19 (

Indexed as

COVID-19AdultHumansImmunocompromised HostRetrospective StudiesSARS-CoV-2COVID-19deltahospitalizationimmunocompromised hostomicron

Identifiers

PMID36560741
PMCPMC9783877

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.