Evidence map›Paper›PMID 36563678›Full record

ArticleNeuron2023

Local memory allocation recruits memory ensembles across brain regions.

Ayal Lavi, Megha Sehgal, Andre F de Sousa, Donara Ter-Mkrtchyan, Fardad Sisan, Alessandro Luchetti, Anna Okabe, Cameron Bear, Alcino J Silva

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Local Neuronal Ensembles That Coreactivate across Regions during Sleep Are Preferentially Stabilized.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Review
  3. Review
  4. A neural mechanism for learning from delayed postingestive feedback.bioRxiv : the preprint server for biology · 2024
    Article
  5. Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024
    Review
  6. Article
  7. Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ayal LaviDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Megha SehgalDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Andre F de SousaDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Donara Ter-MkrtchyanDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Fardad SisanDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Alessandro LuchettiDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Anna OkabeDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Cameron BearDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Alcino J SilvaDepartments of Neurobiology, Psychology, Psychiatry, Integrative Center for Learning and Memory and Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: silvaa@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingRF1AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2022
$4.9M
Molecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingR01AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani · 1995 to 2026
$3.3M
Molecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric DisordersR01MH113071 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$2.3M
NIA NIH HHS R01 AG013622NIA NIH HHS RF1 AG013622NIMH NIH HHS R01 MH113071
6 · The paper itself

Abstract

Memories are thought to be stored in ensembles of neurons across multiple brain regions. However, whether and how these ensembles are coordinated at the time of learning remains largely unknown. Here, we combined CREB-mediated memory allocation with transsynaptic retrograde tracing to demonstrate that the allocation of aversive memories to a group of neurons in one brain region directly affects the allocation of interconnected neurons in upstream brain regions in a behavioral- and brain region-specific manner in mice. Our analysis suggests that this cross-regional recruitment of presynaptic neurons is initiated by downstream memory neurons through a retrograde mechanism. Together with statistical modeling, our results indicate that in addition to the anterograde flow of information between brain regions, the establishment of interconnected, brain-wide memory traces relies on a retrograde mechanism that coordinates memory ensembles at the time of learning.

Indexed as

LearningMemoryAnimalsBrainMiceNeuronsauditory fear conditioningconditioned taste aversionCREBcross-regional recruitmentmemory allocationmemory coordinationmemory ensemblerabiesretrograde mechanism

Identifiers

PMID36563678
PMCPMC10548338
OpenAlexW4312128753

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.