Evidence map›Paper›PMID 36567321›Full record

ArticleActa neuropathologica communications2022

Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor.

Samuele Negro, Fabio Lauria, Marco Stazi, Toma Tebaldi, Giorgia D'Este, Marco Pirazzini, Aram Megighian, Francesca Lessi, Chiara M Mazzanti, Gabriele Sales and 8 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 3 countries.

Samuele Negro *Department of Biomedical Sciences, University of Padua, 35131, Padua, Italy.
Fabio Lauria *Institute of Biophysics, CNR Unit at Trento, 38123, Povo, Italy.
Marco Stazi *Department of Biomedical Sciences, University of Padua, 35131, Padua, Italy.
Toma TebaldiDepartment of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Povo, Italy.
Giorgia D'EsteDepartment of Biomedical Sciences, University of Padua, 35131, Padua, Italy.
Marco PirazziniDepartment of Biomedical Sciences, University of Padua, 35131, Padua, Italy.
Aram MegighianDepartment of Biomedical Sciences, University of Padua, 35131, Padua, Italy.
Francesca LessiLaboratory of Genomics, Pisa Science Foundation, 56017, San Giuliano Terme, Italy.
Chiara M MazzantiLaboratory of Genomics, Pisa Science Foundation, 56017, San Giuliano Terme, Italy.
Gabriele SalesDepartment of Biology, University of Padua, 35131, Padua, Italy.
Chiara RomualdiDepartment of Biology, University of Padua, 35131, Padua, Italy.
Silvia FilloCenter of Medical and Veterinary Research of the Ministry of Defence, 00184, Rome, Italy.
Florigio ListaCenter of Medical and Veterinary Research of the Ministry of Defence, 00184, Rome, Italy.
James N SleighDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Andrew P TosoliniDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Giampietro SchiavoDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.
Gabriella VieroInstitute of Biophysics, CNR Unit at Trento, 38123, Povo, Italy.
Michela RigoniDepartment of Biomedical Sciences, University of Padua, 35131, Padua, Italy. michela.rigoni@unipd.it.ORCID 0000-0003-1763-2648
University of Padua · ITFondazione Pisa · ITMinistry of Defence · ITUK Dementia Research Institute · GBNational Hospital for Neurology and Neurosurgery · GBUniversity of Trento · IT

Funding

Medical Research Council MR/S006990/1Wellcome Trust
6 · The paper itself

Abstract

Regeneration of the neuromuscular junction (NMJ) leverages on extensive exchange of factors released from motor axon terminals (MATs), muscle fibers and perisynaptic Schwann cells (PSCs), among which hydrogen peroxide (H

Indexed as

AxonsConnective Tissue Growth FactorHydrogen PeroxideNerve RegenerationPeripheral Nerve InjuriesAnimalsMiceMice, TransgenicSchwann CellsConnective Tissue Growth FactorHydrogen PeroxideConnective tissue growth factorHydrogen peroxideNerve regenerationNeuromuscular junctionSchwann cellsYes-associated protein

Identifiers

PMID36567321
PMCPMC9791753
OpenAlexW4313199715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.