Evidence map›Paper›PMID 36570532›Full record

ReviewFrontiers in aging neuroscience2022

Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies.

Dan Shan, Shaoyang Li, Ruichen Xu, Glen Nie, Yangyiran Xie, Junchu Han, Xiaoyi Gao, Yuandian Zheng, Zhen Xu, Zhihao Dai

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. Article
  6. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
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  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Characterization of cognitive symptoms in post COVID-19 patients.European archives of psychiatry and clinical neuroscience · 2024
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Dan ShanDepartment of Biobehavioral Sciences, Columbia University, New York, NY, United States.
Shaoyang LiFaculty of Science, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
Ruichen XuDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, WI, United States.
Glen NieDepartment of Biological Science, Northeastern University, Boston, MA, United States.
Yangyiran XieSchool of Medicine, Vanderbilt University, Nashville, TN, United States.
Junchu HanNew York State Psychiatric Institute, Global Psychiatric Epidemiology Group, New York, NY, United States.
Xiaoyi GaoSchool of Medicine, Saint Louis University, St. Louis, MO, United States.
Yuandian ZhengDepartment of Biobehavioral Sciences, Columbia University, New York, NY, United States.
Zhen XuMinhang Crosspoint Academy at Shanghai Wenqi Middle School, Shanghai, China.
Zhihao DaiSchool of Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Ireland.
Columbia University · USHong Kong Polytechnic University · HKNew York State Psychiatric InstituteNortheastern University · USRoyal College of Surgeons in Ireland · IESaint Louis University · USUniversity of Wisconsin–Madison · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, including memory dysfunction. In this PRISMA-based systematic review, we compared and summarized the current literature looking at the relationship between COVID-19-induced neuropathological changes by neuroimaging scans and memory symptoms experienced by patients who recovered from COVID-19. Overall, this review suggests a correlational trend between structural abnormalities (e.g., cortical atrophy and white matter hyperintensities) or functional abnormalities (e.g., hypometabolism) in a wide range of brain regions (particularly in the frontal, parietal and temporal regions) and memory impairments in COVID-19 survivors, although a causal relationship between them remains elusive in the absence of sufficient caution. Further longitudinal investigations, particularly controlled studies combined with correlational analyses, are needed to provide additional evidence.

Indexed as

brainCOVID-19memory impairmentMRIneuroimagingPET

Identifiers

PMID36570532
PMCPMC9780393
OpenAlexW4311946833

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.