ReviewBMC medicine2022
Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions.
Review in BMC medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Heart Failure with Preserved Ejection Fraction in Women: Sex-Specific Insights Across the Continuum from Diagnosis to Outcomes.Current cardiology reports · 2026Review
- Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review).International journal of molecular medicine · 2026Review
- Sex Differences in Age-Associated Concentric Remodeling and Diastolic Dysfunction.JACC. Advances · 2026Article
- Incorporating angina into the HOpen heart · 2026Article
- Comparative analysis of metabolic and functional cardiac alterations in diet- and genetically induced mouse models of cardiac dysfunction.The FEBS journal · 2026Article
- Seeking Novel Personalized and Sex-Specific Strategies for the Prevention and Treatment of Heart Failure Based on the Assessment of β1-Adrenergic Receptor Desensitization: The Contribution to the HEAL ITALIA Project.Current issues in molecular biology · 2026Article
- Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.The journal of cardiovascular aging · 2026Article
- Quantitative myocardial hypoperfusion on coronary CTA: correlation with left atrial and left ventricular functional parameters.Polish journal of radiology · 2026Article
- Frailty as an independent predictor of one-year outcomes in patients with HFpEF after acute myocardial infarction: insights from a multicenter retrospective cohort in China.Journal of geriatric cardiology : JGC · 2025Article
- Vascular function in women with heart failure with preserved ejection fraction: a mismatch beyond diastole.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Reductions in Epicardial Adipose Tissue and Mediastinal Fat Are Associated with Improved Cardiac Function.Obesity surgery · 2025Article
- Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study.Cardiovascular diabetology · 2025Article
- Gender-Specific Differences in Diastolic Dysfunction and HFpEF: Pathophysiology, Diagnosis, and Therapeutic Strategies.Journal of cardiovascular development and disease · 2025Review
- The contribution of a short electrocardiographic diastolic interval to diastolic dysfunction and HFpEF.BMC cardiovascular disorders · 2025Article
- Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.Nutrients · 2025Review
- Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis.Cardiovascular diabetology · 2025Article
- Incident HFpEF and time-dependent changes in markers of LVDD severity in women and men with preclinical LVDD.Open heart · 2025Article
- The Possible Role of Rosuvastatin Therapy in HFpEF Patients-A Preliminary Report.Diagnostics (Basel, Switzerland) · 2024Article
- Sex differences in atrial fibrillation ablation outcomes in patients with heart failure.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Echocardiographic characterization of age- and sex-associated differences in cardiac function and morphometry in nonhuman primates.GeroScience · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Diastolic dysfunction of the left ventricle (LVDD) is equally common in elderly women and men. LVDD is a condition that can remain latent for a long time but is also held responsible for elevated left ventricular filling pressures and high pulmonary pressures that may result in (exercise-induced) shortness of breath. This symptom is the hallmark of heart failure with preserved ejection fraction (HFpEF) which is predominantly found in women as compared to men within the HF spectrum. Given the mechanistic role of LVDD in the development of HFpEF, we review risk factors and mechanisms that may be responsible for this sex-specific progression of LVDD towards HFpEF from an epidemiological point-of-view and propose future research directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.