Evidence map›Paper›PMID 36575865›Full record

Trial reportCNS neuroscience & therapeutics2023

Motor network reorganization after motor imagery training in stroke patients with moderate to severe upper limb impairment.

Hewei Wang, Xin Xiong, Kexu Zhang, Xu Wang, Changhui Sun, Bing Zhu, Yiming Xu, Mingxia Fan, Shanbao Tong, Xiaoli Guo and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07553416 (A Prospective, Randomized, Parallel-Controlled Clinical Study Protocol of Non-Invasive Brain Computer Interface Robot Based on Mirror Rehabilitation Theory in the Treatment of Upper Limb Motor Function Disorder After Stroke), which is not on this map. Cited by 44 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 9 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07553416 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Prospective, Randomized, Parallel-Controlled Clinical Study Protocol of Non-Invasive Brain Computer Interface Robot Based on Mirror Rehabilitation Theory in the Treatment of Upper Limb Motor Function Disorder After Stroke

TypeinterventionalSponsorBeijing Tiantan HospitalRan2026 to 2027Enrolled40ConditionsIschemic Stroke, Intracranial Haemorrhage, Brain-Computer Interfaces, Rehabilitation ExerciseArmsBrain computer interface-robotic mirror therapy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 9 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hewei WangDepartment of Rehabilitation Medicine, Huashan Hospital Fudan University, Shanghai, China.ORCID 0000-0001-7632-0607
Xin XiongSchool of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Kexu ZhangSchool of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Xu WangSchool of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Changhui SunDepartment of Rehabilitation Medicine, Huashan Hospital Fudan University, Shanghai, China.
Bing ZhuDepartment of Rehabilitation Medicine, Huashan Hospital Fudan University, Shanghai, China.
Yiming XuDepartment of Rehabilitation Medicine, Huashan Hospital Fudan University, Shanghai, China.
Mingxia FanShanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Shanbao TongSchool of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.
Xiaoli GuoSchool of Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China.ORCID 0000-0002-6346-1846
Limin SunDepartment of Rehabilitation Medicine, Huashan Hospital Fudan University, Shanghai, China.
Fudan University · CNShanghai Jiao Tong University · CNEast China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMotor imagery training (MIT) has been widely used to improve hemiplegic upper limb function in stroke rehabilitation. The effectiveness of MIT is associated with the functional neuroplasticity of the motor network. Currently, brain activation and connectivity changes related to the motor recovery process after MIT are not well understood.

aimWe aimed to investigate the neural mechanisms of MIT in stroke rehabilitation through a longitudinal intervention study design with task-based functional magnetic resonance imaging (fMRI) analysis.

methodsWe recruited 39 stroke patients with moderate to severe upper limb motor impairment and randomly assigned them to either the MIT or control groups. Patients in the MIT group received 4 weeks of MIT therapy plus conventional rehabilitation, while the control group only received conventional rehabilitation. The assessment of Fugl-Meyer Upper Limb Scale (FM-UL) and Barthel Index (BI), and fMRI scanning using a passive hand movement task were conducted on all patients before and after treatment. The changes in brain activation and functional connectivity (FC) were analyzed. Pearson's correlation analysis was conducted to evaluate the association between neural functional changes and motor improvement.

resultsThe MIT group achieved higher improvements in FM-UL and BI relative to the control group after the treatment. Passive movement of the affected hand evoked an abnormal bilateral activation pattern in both groups before intervention. A significant Group × Time interaction was found in the contralesional S1 and ipsilesional M1, showing a decrease of activation after intervention specifically in the MIT group, which was negatively correlated with the FM-UL improvement. FC analysis of the ipsilesional M1 displayed the motor network reorganization within the ipsilesional hemisphere, which correlated with the motor score changes.

conclusionsMIT could help decrease the compensatory activation at both hemispheres and reshape the FC within the ipsilesional hemisphere along with functional recovery in stroke patients.

Indexed as

StrokeStroke RehabilitationBrainHumansMagnetic Resonance ImagingRecovery of FunctionUpper Extremityfunctional connectivitymotor imagery trainingstroke rehabilitationtask-based fMRIupper limb function

Identifiers

PMID36575865
PMCPMC9873524
OpenAlexW4313236620

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.