ArticleeLife2022
Computational design of peptides to target Na
Open access · goldAbstract read
In one paragraph
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 25 citations in OpenAlex.
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- Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions.Neural regeneration research · 2026Article
- Osteoarthritis: molecular pathogenesis and potential therapeutic options.Signal transduction and targeted therapy · 2026Review
- Exercise-mediated regulation of mitochondrial dynamics in aging muscle: implications for mitochondrial diseases.Molecular and cellular biochemistry · 2026Review
- Review
- Recent advances in the pharmacology of voltage-gated ion channels.Pharmacological reviews · 2025Review
- Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.The Journal of clinical investigation · 2025Article
- Article
- Abnormal iron metabolism in the zona incerta in Parkinson's disease mice.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Refining the NaFEBS letters · 2025Article
- Voltage-gated sodium channels in excitable cells as drug targets.Nature reviews. Drug discovery · 2025Review
- Discordance between preclinical and clinical testing of Na V 1.7-selective inhibitors for pain.Pain · 2025Review
- Harnessing Deep Learning Methods for Voltage-Gated Ion Channel Drug Discovery.Physiology (Bethesda, Md.) · 2025Review
- Novel non-opioid analgesics in pain management.Pain management · 2024Review
- Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods.Current pain and headache reports · 2024Review
- Leveraging a meta-learning approach to advance the accuracy of NaScientific reports · 2024Article
- Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations.Nature communications · 2024Article
- Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel.The Journal of general physiology · 2024Article
- Venom-derived peptides for breaking through the glass ceiling of drug development.Frontiers in chemistry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 2 countries.
Phuong T Nguyen *Department of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-9461-7807
Hai M Nguyen *Department of Pharmacology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-1422-7041
Karen M WagnerDepartment of Entomology and Nematology & Comprehensive Cancer Center, University of California Davis, Davis, United States.
Robert G StewartDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.
Vikrant SinghDepartment of Pharmacology, University of California Davis, Davis, United States.
Parashar ThapaDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.
Yi-Je ChenDepartment of Pharmacology, University of California Davis, Davis, United States.
Mark W LillyaDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.
Anh Tuan TonAnaBios Corporation, San Diego, United States.
Richard KondoAnaBios Corporation, San Diego, United States.
Andre GhettiAnaBios Corporation, San Diego, United States.
Michael W PenningtonAmbiopharm Inc, North Augusta, United States.ORCID https://orcid.org/0000-0001-5446-3447
Bruce HammockDepartment of Entomology and Nematology & Comprehensive Cancer Center, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0003-1408-8317
Theanne N GriffithDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0003-0090-6286
Jon T SackDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-6975-982X
Heike WulffDepartment of Pharmacology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0003-4437-5763
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California Davis, Davis, United States.ORCID https://orcid.org/0000-0002-2325-4834
University of California, Davis · USAnaBios (United States) · USDebiopharm (Switzerland) · CH
Funding
Optimization of non-addictive biologics to target sodium channels involved in pain signalingUG3NS114956 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WULFF, HEIKE, YAROV-YAROVOY, VLADIMIR M · 2019 to 2019
$1.6MNINDS NIH HHS UG3 NS114956
Abstract
The voltage-gated sodium Na
Indexed as
NAV1.7 Voltage-Gated Sodium ChannelPainPeptidesVoltage-Gated Sodium Channel BlockersAnimalsDrug DesignHumansMiceNociceptorsRatsSpider VenomsNAV1.7 Voltage-Gated Sodium ChannelPeptidesSpider VenomsVoltage-Gated Sodium Channel Blockersmolecular biophysicsmousepainpeptide toxinsprotein designratrosettasodium channelsstructural biology
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.