ReviewClinical oral investigations2023
Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis.
Review in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06398327 (Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy Of Proinflammatory Cytokines in the Clinical And Radiographic Outcomes of Different Primary Molar Pulpotomy Agents: A Comparative Study Featuring A Novel Biomarker For Pulpal Diagnosis
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Mapping Systematic Reviews on the Management of Dental Caries in Primary Teeth: A Meta-research.Current pediatric reviews · 2026Pooled it
- Pooled it
- Clinical and radiographic outcomes of three calcium silicate-based cements in primary tooth pulpotomy: a randomized clinical trial.BMC oral health · 2026Trial
- Treatment outcomes of pulpotomy in primary molars utilizing 2.25% sodium hypochlorite gel: a randomized controlled trial.BMC oral health · 2025Trial
- Trial
- Assessment of sealing ability, antibacterial effect and marginal adaptation of bioactive materials in pulpotomized primary molars: an in-vitro study.BMC oral health · 2026Article
- Do Restorative Strategies and Delayed Restoration Improve the Bond Strength to Biodentine? In Vitro Study on Adhesive Restorations on a Calcium Silicate-Based Cement.The journal of adhesive dentistry · 2025Article
- Laser Pulpotomies' Clinical and Radiographic Success in Primary Teeth by Type of Laser.Children (Basel, Switzerland) · 2025Review
- Vital Pulp Therapy: Evidence-Based Techniques and Outcomes.Iranian endodontic journal · 2025Review
- Pulpotomy in primary teeth: Biodentine™ versus calcium hydroxide. A systematic review and meta-analysis.The Saudi dental journal · 2024Review
- Clinical and radiographic success of TheraCal versus Formocresol in primary teeth pulpotomy: A systematic review andThe Saudi dental journal · 2024Review
- Article
- Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study.BMC oral health · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe performed this network meta-analysis to determine the comparative efficacy of formocresol (FC), ferric sulfate (FS), sodium hypochlorite (NaOCl), calcium hydroxide (CH), mineral trioxide aggregate (MTA), biodentine, and laser for pulpotomy of molar teeth. MATERIALS AND
methodsAn updated search was conducted in PubMed, Embase, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) published before October 30, 2022, after screening previous meta-analyses. The Cochrane risk of bias assessment tool was used to appraise the methodological quality of included studies. Clinical and radiographic success rates were assessed as outcomes. Random network meta-analysis was performed by using STATA software (version 14.0) with "network" command.
resultsA total of 43 RCTs were included. Network meta-analysis indicated that CH was inferior to other medicaments and techniques in all outcomes, and MTA and biodentine was better than FC, FS, and NaOCl in terms of clinical and radiographic success rates. Results of ranking probabilities suggested that MTA ranked first in all outcomes except for clinical success at both 6 months.
conclusionsOur results suggested that MTA was associated with significant improvement in both clinical and radiographic success than other pulpotomy medicaments and techniques, with the highest probability of being the optimal option. CLINICAL RELEVANCE: The current network meta-analysis determined the comparative efficacy and safety of 7 common pulpotomy medicaments in molar pulpotomy, including FC, FS, NaOCl, CH, MTA, biodentine, and laser, and the pooled results revealed comparable efficacy in clinical and radiographic success rates at 6 and 12 months between FC, FS, and NaOCl in primary molars pulpotomies. However, MTA, biodentine and laser may have more advantages than other pulpotomy medicaments for clinical and radiographic success. Therefore, in clinical practice, practitioners should select MTA, biodentine, or laser as pulpotomy medicaments in molar pulpotomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.