ArticleImmunity2023
CD8
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06292052 (Relation Between Tumor-draining Lymph Nodes Metastasis Pattern and Non-small Cell Lung Cancer Neoadjuvant Immunotherapy Effectiveness), which is not on this map. Cited by 240 papers.
0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed
24.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relation Between Tumor-draining Lymph Nodes Metastasis Pattern and Non-small Cell Lung Cancer Neoadjuvant Immunotherapy Effectiveness: A Retrospective Multi-institutional Cohort Analysis
Who cites it
240 citing papers in PubMed, 315 citations in OpenAlex.
- Neoadjuvant cabozantinib for locally advanced nonmetastatic clear cell renal cell carcinoma: a phase 2 trial.Nature cancer · 2025Trial
- Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer.Cell reports. Medicine · 2024Trial
- Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research.Oncoimmunology · 2026Review
- Tumor-Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy-Immunotherapy Combination Trials.International journal of cancer · 2026Review
- Prognostic Value of Perioperative Inflammatory-Immune-Nutritional Indicators in Advanced Gallbladder Cancer.Cancer medicine · 2026Article
- Article
- Efficient generation of human cDC1-like cells to detect and enhance tumor-reactive T cells via CD4Cell reports methods · 2026Article
- Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design.Molecular cancer · 2026Review
- Epigenetic plus cytokine therapy induces stem-like CD8Journal for immunotherapy of cancer · 2026Article
- Tumor cell-expressed OX40L enhances the efficacy of PD-1 axis blockade in non-small cell lung cancer.Journal for immunotherapy of cancer · 2026Article
- Photothermal-driven sequential immunotherapy overcomes resistance to PARP inhibition inActa pharmaceutica Sinica. B · 2026Article
- Molecular heterogeneity and clonal origin of CCR8Nature communications · 2026Article
- Tumor-distal mediastinal lymph nodes harbor tumor-related progenitor exhausted T cells in lung cancer after neoadjuvant chemoimmunotherapy.Cell reports. Medicine · 2026Article
- Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.The Journal of clinical investigation · 2026Review
- Spatial Immune Coding in Tumor-Draining Lymph Nodes: Functional Compartmentalization of Immune Activation and Immunosuppression.International journal of molecular sciences · 2026Review
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Dendritic cell redundancy enables priming of anti-tumor CD4Cancer cell · 2026Article
- Tumor infiltrating lymphocytes in glioblastoma: immunobiology and translational implications.NPJ precision oncology · 2026Review
180 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Nataliya ProkhnevskaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Maria A CardenasDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Rajesh M ValanparambilDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Ewelina SobierajskaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Benjamin G BarwickWinship Cancer Institute of Emory University, Atlanta, GA, USA; Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Caroline JansenDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Adriana Reyes MoonDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Petra GregorovaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Luke delBalzoDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Rachel GreenwaldDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Mehmet Asim BilenWinship Cancer Institute of Emory University, Atlanta, GA, USA; Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Mehrdad AlemozaffarDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Shreyas JoshiDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Cara CimminoDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Christian LarsenEmory Transplant Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Viraj MasterDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Martin SandaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA.
Haydn KissickDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA; Winship Cancer Institute of Emory University, Atlanta, GA, USA; Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: haydn.kissick@emory.edu.
Emory University · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MImplementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MProstate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas SouthwesternU01CA113913 · NCI · EMORY UNIVERSITY · PI Martin G. Sanda · 2005 to 2026
$16.4MIllumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985kEpigenetic Mechanisms Controlling T-cell Exhaustion in Prostate CancerR00CA197804 · NCI · EMORY UNIVERSITY · PI KISSICK, HAYDN · 2018 to 2020
$747kNCATS NIH HHS UL1 TR002378NCI NIH HHS L30 CA231673NCI NIH HHS R00 CA197804NCI NIH HHS U01 CA113913NIH HHS P51 OD011132NIH HHS S10 OD026799
Abstract
Improvements in tumor immunotherapies depend on better understanding of the anti-tumor T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that activated CD8
Indexed as
CD8-Positive T-LymphocytesNeoplasmsAnimalsCell DifferentiationHumansLymph NodesLymphocyte ActivationMiceantigen-presenting cellscancerCD8 T cellsco-stimulationT cell differentiationT cell exhaustiontumor-draining lymph nodestumor-infiltrating lymphocytes
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06292052ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.