Observational studyESC heart failure2023
Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients.
Observational study in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- Heart Failure and Atrial Fibrillation in Women: Pathophysiological Links, Clinical Challenges, and Therapeutic Perspectives.Medicina (Kaunas, Lithuania) · 2026Review
- Sex differences in leptin levels but not in the leptin response to sacubitril/valsartan in patients with heart failure with reduced ejection fraction.Frontiers in cardiovascular medicine · 2026Article
- One-year post-discharge health-related quality of life in digestive and oncology patients: a three-group comparison by nutritional status and care.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Females and Exercise Capacity Impairment in Heart Failure: A Sex-Focused Analysis.Journal of cardiovascular development and disease · 2025Article
- Sociodemographic, disease-related and lifestyle determinants of health-related quality of life among older patients hospitalized with heart failure.Scientific reports · 2025Article
- The Association Between Chronic Heart Failure and Metabolic Syndrome Increases the Cost of Hospitalization.Healthcare (Basel, Switzerland) · 2025Article
- Patient-Reported Outcome-Based, Comprehensive Assessment of Quality of Life of Adults with Congenital Heart Disease in India.Global heart · 2025Article
- Sex-specific differences in risk factors, comorbidities, diagnostic challenges, optimal management, and prognostic outcomes of heart failure with preserved ejection fraction: A comprehensive literature review.Heart failure reviews · 2024Review
- Impairments in quality of life and predictors of symptom burden in patients with hypoparathyroidism: results from a population-based survey.Endocrine · 2023Article
- Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients.Journal of personalized medicine · 2023Article
- Psychosocial factors partially explain gender differences in health-related quality of life in heart failure patients.ESC heart failure · 2023Observational
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is little information about the influence of gender on quality of life (QoL) in heart failure. The purpose of this study was to evaluate whether the health-related QoL gap between men and women can be explained by the interaction between psychosocial factors and clinical determinants in a real-word cohort of patients with chronic heart failure. METHODS AND
resultsWe conducted a single-centre, observational, prospective cohort study of 1236 consecutive patients diagnosed with chronic heart failure recruited between 2004 and 2014. To assess QoL, we used the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Female gender was associated with worse global QoL compared to male gender (MLHFQ overall summary score: 49 ± 23 vs. 43 ± 24; P value <0.001, respectively) and similarly had poorer scores in physical and emotional dimensions but scored better on social dimension. In univariate models and in models adjusted for clinical determinants, female gender behaved as a predictor of worse global, physical and emotional QoL, and better social QoL compared with men. In models only including psychosocial determinants and in comprehensive models including all psychosocial and clinical factors, these differences according to gender were no longer significant.
conclusionsIn this study, we have shown that the gap in health-related QoL between men and women with chronic heart failure can be partially explained by the interaction between biological and psychosocial factors. Biological factors are the main drivers of QoL in HF patients. However, the contribution of psychosocial factors is essential to definitively understand the role of gender in this field.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.