Evidence map›Paper›PMID 36589263›Full record

ArticleClinical research in HIV/AIDS2022

Dasatinib: effects on the macrophage phospho proteome with a focus on SAMHD1 and HIV-1 infection.

Elizabeth S C P Williams, Matthew A Szaniawski, Laura J Martins, Emily A Innis, José Alcamí, Timothy M Hanley, Adam M Spivak, Mayte Coiras, Vicente Planelles

Open access · greenAbstract read
In one paragraph

Article in Clinical research in HIV/AIDS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Sustained antiviral response againstFrontiers in pharmacology · 2024
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Elizabeth S C P WilliamsUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
Matthew A SzaniawskiUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
Laura J MartinsUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
Emily A InnisUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
José AlcamíAIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Timothy M HanleyUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
Adam M SpivakUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
Mayte CoirasAIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
Vicente PlanellesUniversity of Utah School of Medicine, Department of Pathology, Salt Lake City, UT.
University of Utah · USInstituto de Salud Carlos III · ES

Funding

Tyrosine Kinase inhibition: The New Front in HIV Cure EffortsR01AI143567 · NIAID · UNIVERSITY OF UTAH · PI COIRAS, MAYTE, PLANELLES, VICENTE · 2019 to 2023
$2.3M
NRSA Training CoreTL1TR002540 · NCATS · UNIVERSITY OF UTAH · PI FAGERLIN, ANGELA, FAIRFAX, KEKE CELESTE · 2018 to 2022
$1.6M
NCATS NIH HHS TL1 TR002540NIAID NIH HHS R01 AI143567
6 · The paper itself

Abstract

Macrophages are one of the main cellular targets of human immunodeficiency virus type 1 (HIV-1). Macrophage infection by HIV-1 is inefficient due to the presence of the viral restriction factor sterile alpha motif and histidine aspartic acid domain containing protein 1 (SAMHD1).

Indexed as

CDK1CDK4cell cycleDasatinibHIV-1macrophagesphosphoproteomeSAMHD1serine/threonine kinasetyrosine kinase

Identifiers

PMID36589263
PMCPMC9802671
OpenAlexW4313488158

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.