ArticleFrontiers in aging neuroscience2022
Associations between repetitive negative thinking and resting-state network segregation among healthy middle-aged adults.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Change in Resting-State Functional Connectivity Following Working Memory Training in Individuals With Repetitive Negative Thinking.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Trial
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Sex differences in the association between repetitive negative thinking and neurofilament light.Npj mental health research · 2024Article
- Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults.Brain connectivity · 2024Article
- Impact of repetitive negative thinking on subjective cognitive decline: insights into cognition and brain structure.Frontiers in aging neuroscience · 2024Article
- Purpose in life promotes resilience to age-related brain burden in middle-aged adults.Alzheimer's research & therapy · 2023Article
- Article
- Brain system segregation and pain catastrophizing in chronic pain progression.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Repetitive Negative Thinking (RNT) includes negative thoughts about the future and past, and is a risk factor for depression and anxiety. Prefrontal and anterior cingulate cortices have been linked to RNT but several regions within large-scale networks are also involved, the efficiency of which depends on their ability to remain segregated. Methods: Associations between RNT and system segregation (SyS) of the Anterior Salience Network (ASN), Default Mode Network (DMN) and Executive Control Network (ECN) were explored in healthy middle-aged adults ( Results: Analyses indicated that RNT was associated with depression, emotional stability, cognitive complaints, age and segregation of the left ECN (LECN) and ASN. Further, the ventral DMN (vDMN) presented higher connectivity with the ASN and decreased connectivity with the LECN, as a function of RNT. Conclusion: Higher levels of perseverative thinking were related to increased segregation of the LECN and decreased segregation of the ASN. The dissociative connectivity of these networks with the vDMN may partially account for poorer cognitive control and increased self-referential processes characteristic of RNT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.