Evidence map›Paper›PMID 36593913›Full record

ReviewMaterials today. Bio2023

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration.

Yikun Ju, Yue Hu, Pu Yang, Xiaoyan Xie, Bairong Fang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 270 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
270citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

270 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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210 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yikun JuDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.
Yue HuSchool of Clinical Medicine, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.
Pu YangDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.
Xiaoyan XieDepartment of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.
Bairong FangDepartment of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are a collective term for nanoscale or microscale vesicles secreted by cells that play important biological roles. Mesenchymal stem cells are a class of cells with the potential for self-healing and multidirectional differentiation. In recent years, numerous studies have shown that EVs, especially those secreted by mesenchymal stem cells, can promote the repair and regeneration of various tissues and, thus, have significant potential in regenerative medicine. However, due to the rapid clearance capacity of the circulatory system, EVs are barely able to act persistently at specific sites for repair of target tissues. Hydrogels have good biocompatibility and loose and porous structural properties that allow them to serve as EV carriers, thereby prolonging the retention in certain specific areas and slowing the release of EVs. When EVs are needed to function at specific sites, the EV-loaded hydrogels can stand as an excellent approach. In this review, we first introduce the sources, roles, and extraction and characterization methods of EVs and describe their current application status. We then review the different types of hydrogels and discuss factors influencing their abilities to carry and release EVs. We summarize several strategies for loading EVs into hydrogels and characterizing EV-loaded hydrogels. Furthermore, we discuss application strategies for EV-loaded hydrogels and review their specific applications in tissue regeneration and repair. This article concludes with a summary of the current state of research on EV-loaded hydrogels and an outlook on future research directions, which we hope will provide promising ideas for researchers.

Indexed as

4-arm-PEG-MAL, four-armed polyethylene glycol (PEG) functionalized with maleimide groupAD/CS/RSF, alginate-dopamine chondroitin sulfate and regenerated silk fibroinADSC, Adipose derived mesenchymal stem cellsADSC-EVs, adipose mesenchymal stem cells derived EVsADSC-Exos, adipose mesenchymal stem cells derived exosomesATRP, Atom transfer radical polymerizationBCA, bicinchoninic acidBMSC, Bone marrow mesenchymal stem cellsBMSC-EVs, bone marrow mesenchymal stem cells derived EVsBMSC-Exos, bone marrow mesenchymal stem cells derived exosomesCGC, chitosan-gelatin-chondroitin sulfateCL, chitosan lactateCNS, central nervous systemCPCs, cardiac progenitor cellsCS-g-PEG, chitosan-g-PEGdECM, decellularized ECMDPSC-Exos, dental pulp stem cells derived exosomesECM, extracellular matrixEGF, epidermal growth factorEVMs, extracellular vesicles mimeticsEVs, Extracellular vesiclesExos, ExosomesExosomeExtracellular vesicleFEEs, functionally engineered EVsFGF, fibroblast growth factorGelMA, Gelatin methacryloylHA, Hyaluronic acidHAMA, Hyaluronic acid methacryloylHG, nano-hydroxyapatite-gelatinHIF-1 α, hypoxia-inducible factor-1 αhiPS-MSC-Exos, human induced pluripotent stem cell-MSC-derived exosomesHS-HA, hypoxia-sensitive hyaluronic acidHUVEC, human umbilical vein endothelial cellHydrogeliPS-CPCs, pluripotent stem cell-derived cardiac progenitorsLAP, Lithium Phenyl (2,4,6-trimethylbenzoyl) phosphinateLSCM, laser scanning confocal microscopyMC-CHO, Aldehyde methylcelluloseMMP, matrix metalloproteinaseMNs, microneedlesMSC-EVs, mesenchymal stem cells derived EVsMSC-Exos, mesenchymal stem cells derived exosomesMSCs, mesenchymal stem cellsnHP, nanohydroxyapatite/poly-ε-caprolactoneNPCs, neural progenitor cellsNTA, nanoparticle tracking analysisOHA, oxidized hyaluronic acidOSA, oxidized sodium alginatePDA, PolydopaminePDLLA, poly(D l-lactic acid)PDNPs-PELA, Polydopamine nanoparticles incorporated poly (ethylene glycol)-poly(ε-cap-rolactone-co-lactide)PEG, Polyethylene glycolPF-127, Pluronic F-127PHEMA, phenoxyethyl methacrylatePIC, photo-induced imine crosslinkingPKA, protein kinase A systemPLA, Poly lactic acidPLGA, polylactic acid-hydroxy acetic acid copolymerPLLA, poly(l-lactic acid)PPy, polypyrrolePVA, polyvinyl alcoholRDRP, Reversible deactivation radical polymerizationRegenerationSCI, spinal cord injurySEM, Scanning electron microscopysEVs, small extracellular vesiclesSF, Silk fibroinSPT, single-particle trackingTEM, transmission electron microscopyTissue repairUMSC-EVs, umbilical cord mesenchymal stem cells derived EVsUMSC-Exos, umbilical cord mesenchymal stem cells derived exosomesUMSC, umbilical cord mesenchymal stem cellsUV, ultravioletVEGF-R, vascular endothelial growth factor receptorVEGF, vascular endothelial growth factorWB, western blottingβ-TCP, β-Tricalcium Phosphate

Identifiers

PMID36593913
PMCPMC9803958

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.