Evidence map›Paper›PMID 36595571›Full record

ArticleScience signaling2023

Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.

Neal Beeman, Tanmay Sapre, Shao-En Ong, Smita Yadav

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
5.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Expanding the phenotype and genotype spectrum of TAOK1 neurodevelopmental disorder and delineating TAOK2 neurodevelopmental disorder.Genetics in medicine : official journal of the American College of Medical Genetics · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neal BeemanDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-4466-4944
Tanmay SapreDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5024-1780
Shao-En OngDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-3314-5903
Smita YadavDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5228-9235
University of Washington · US

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
TAOK2 Kinase Signaling in Human Neural Stem Cell DevelopmentR01MH121674 · NIMH · UNIVERSITY OF WASHINGTON · PI YADAV, SMITA · 2020 to 2024
$2.2M
Supplement to DEFINING PATHWAY-SPECIFIC KINASE SIGNALING MODULES WITH PROTEOMICSR01GM129090 · NIGMS · UNIVERSITY OF WASHINGTON · PI ONG, SHAO-EN · 2019 to 2022
$1.7M
A NanoLC-Orbitrap Tribrid Instrument for Comprehensive Proteomics AnalysesS10OD021502 · OD · UNIVERSITY OF WASHINGTON · PI ONG, SHAO-EN · 2017 to 2017
$906k
NICHD NIH HHS P50 HD103524NIGMS NIH HHS R01 GM129090NIH HHS S10 OD021502NIMH NIH HHS R01 MH121674
6 · The paper itself

Abstract

Mutations in

Indexed as

Autism Spectrum DisorderNeurodevelopmental DisordersAnimalsCell MembraneMammalsMiceMutationProtein Serine-Threonine KinasesThreonineProtein Serine-Threonine KinasesThreonine

Identifiers

PMID36595571
PMCPMC9970049
OpenAlexW4313458786

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.