ArticleFrontiers in endocrinology2022
Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review).International journal of molecular medicine · 2026Review
- Case-Control and Longitudinal Study of Sex Steroids in Male Patients with CKD Before and After Kidney Transplantation.Kidney international reports · 2026Article
- The mediatory role of androgens on sex differences in glucose homeostasis and incidence of type 2 diabetes: the KORA study.Cardiovascular diabetology · 2024Observational
- Sex hormone binding globulin (SHBG) serum levels and insulin resistance in men on chronic hemodialysis.Diabetology & metabolic syndrome · 2024Article
- Evaluation of renal disturbance in animal models of polycystic ovary syndrome.Open veterinary journal · 2023Article
- Association of sex hormones and sex hormone-binding globulin with liver fat in men and women: an observational and Mendelian randomization study.Frontiers in endocrinology · 2023Observational
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women. Research design and methods: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. We examined the associations between endogenous androgens (testosterone [T], dihydrotestosterone [DHT], free T [fT], free DHT [fDHT], and T/DHT), with estimated glomerular filtration rate (eGFR) at baseline and follow-up, prevalent, and incident chronic kidney disease (CKD) adjusting for common CKD risk factors. Results: At baseline, 73 men (5.7%) and 54 women (8.4%) had prevalent CKD. Cross-sectionally, no significant associations between androgens and kidney function were observed among men. In women, elevated T (β=-1.305, [95% CI -2.290; -0.320]) and fT (β=-1.423, [95% CI -2.449; -0.397]) were associated with lower eGFR. Prospectively, 81 men (8.8%) and 60 women (15.2%) developed incident CKD. In women, a reverse J-shaped associations was observed between DHT and incident CKD (P Conclusion: Suggestive associations are observed of androgens and SHBG with kidney impairment among men and women. However, larger well-phenotyped prospective studies are required to further elucidate the potential of androgens, SHBG, and T2D as modifiable risk factors for kidney function and CKD.
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