Evidence map›Paper›PMID 36601410›Full record

ArticleMolecular vision2022

In vitro induction and intraocular application in oxygen-induced retinopathy of adipose-derived mesenchymal stem cells.

Lvlv Zhou, Haifeng Zhang, Sarina Wu, Yuhong He, Kai Guo

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lvlv ZhouDepartment of Ophthalmology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Haifeng ZhangDepartment of Physiology, Inner Mongolia Medical University, Inner Mongolia, China.
Sarina WuInner Mongolia Institute of Traditional Chinese Medicine, Inner Mongolia Medical University, Inner Mongolia, China.
Yuhong HeDepartment of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, China.
Kai GuoDepartment of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, China.
Second Affiliated Hospital of Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. Methods: HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. HADSCs were intraocularly injected into oxygen-induced retinopathy (OIR) mice to check the movement, fusion, proliferation, and prognosis in vivo. Electron microscopy was used to check retinal changes to confirm the safety of hADSCs in intraocular application. Results: After induction, hADSCs expressed von Willebrand Factor (vWF), the cell marker of ECs. The hADSCs were distributed above the retina after an intravitreal injection in the OIR mice. The injected cells did not fuse with the retina and gathered in the central and peripheral areas, which is the lesion area of the OIR model. Five days after the hADSC intravitreal injection, the area of ​neovascularization was reduced by 94.83% compared with that of the OIR group. Hematologic staining and electron microscopy did not show noticeable proliferation and degeneration of the retina. Conclusions: This study provides evidence for the intraocular application of hADSCs.

Indexed as

Mesenchymal Stem CellsRetinal DiseasesRetinal NeovascularizationAnimalsDisease Models, AnimalEndothelial CellsHumansMiceMice, Inbred C57BLOxygenRetinaOxygen

Identifiers

PMID36601410
PMCPMC9767843
OpenAlexW4313545508

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.