Evidence map›Paper›PMID 36601916›Full record

ArticleHypertension (Dallas, Tex. : 1979)2023

Continuous Positive Airway Pressure for the Treatment of Supine Hypertension and Orthostatic Hypotension in Autonomic Failure.

Luis E Okamoto, Jorge E Celedonio, Emily C Smith, Sachin Y Paranjape, Bonnie K Black, Amr Wahba, Jin-Woo Park, Cyndya A Shibao, André Diedrich, Italo Biaggioni

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03312556 (Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03312556 narecruitingnot on this map

Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure

TypeinterventionalSponsorVanderbilt University Medical CenterRan2017 to 2026Enrolled12ConditionsSupine Hypertension, Autonomic FailureArmscontinuous positive airway pressure (CPAP), Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. How to treat cardiovascular autonomic failure in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. A reset on our reclined position-a call to prioritize neurogenic supine hypertension in the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Review
  6. Article
  7. Approaches for treating cardiovascular symptoms in Parkinson's disease.Therapeutic advances in neurological disorders · 2025
    Review
  8. Review
  9. Review
  10. Engaging patients in the management of orthostatic intolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Luis E OkamotoVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-6914-7287
Jorge E CeledonioVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.
Emily C SmithVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-5078-6748
Sachin Y ParanjapeVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.
Bonnie K BlackVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.
Amr WahbaVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.
Jin-Woo ParkVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-5548-3378
Cyndya A ShibaoVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-4518-6801
André DiedrichVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.
Italo BiaggioniVanderbilt Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine (L.E.O., J.E.C., E.C.S., S.Y.P., B.K.B., A.W., J.-W.P., C.A.S., A.D., I.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-7667-7083
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 1997 to 2016
$30.8M
Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2009 to 2018
$11.6M
Hemodynamic Effects of Positive Airway Pressure to Treat Supine Hypertension and Improve Neurogenic Orthostatic HypotensionR01HL161095 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Italo Biaggioni, Luis Enrique Okamoto · 2022 to 2026
$3.2M
Automated Abdominal Binder for Orthostatic HypotensionR01HL144568 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OKAMOTO, LUIS ENRIQUE · 2020 to 2024
$2.7M
Autonomic Determinants of Postural Tachycardia SyndromeR01HL142583 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DIEDRICH, ANDRE · 2019 to 2022
$1.7M
Splanchnic Circulation and Blood Pressure RegulationR01HL122847 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2015 to 2018
$1.6M
NCATS NIH HHS UL1 TR000445NHLBI NIH HHS P01 HL056693NHLBI NIH HHS R01 HL122847NHLBI NIH HHS R01 HL142583NHLBI NIH HHS R01 HL144568NHLBI NIH HHS R01 HL161095NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

backgroundSupine hypertension affects most patients with orthostatic hypotension (OH) due to autonomic failure, but it is often untreated for fear of worsening OH. We hypothesized that increasing intrathoracic pressure with continuous positive airway pressure (CPAP) had a Valsalva-like blood-pressure-lowering effect that could be used to treat nocturnal supine hypertension in these patients, while reducing nocturnal pressure diuresis and improving daytime OH.

methodsIn Protocol 1, we determined the acute hemodynamic effects of increasing levels of CPAP (0, 4, 8, 12, and 16 cm H

resultsIn Protocol 1, acute CPAP (4-16 cm H

conclusionsCPAP is a novel nonpharmacologic approach to treat the supine hypertension of autonomic failure while improving nocturia and daytime OH. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03312556.

Indexed as

HypertensionHypotension, OrthostaticPure Autonomic FailureBlood PressureContinuous Positive Airway PressureCross-Over StudiesHumansautonomic failurecontinuous positive airway pressurenocturiaorthostatic hypotensionsupine hypertension

Identifiers

PMID36601916
PMCPMC10128890
OpenAlexW4313546222

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.