Evidence map›Paper›PMID 36604715›Full record

ArticleJournal of nanobiotechnology2023

NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a "One-Stone-Two-Birds" manner.

Guanghao Wu, Qihang Su, Jie Li, Chao Xue, Jie Zhu, Qiuchen Cai, Jingbiao Huang, Shaoyang Ji, Biao Cheng, Hengan Ge

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  4. Biology · 2025
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  5. Review
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  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
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  13. Epigenetic mechanisms in stem cell therapies for achilles tendinopathy.Frontiers in cell and developmental biology · 2025
    Review
  14. Inducing In Situ MBiomaterials research · 2025
    Article
  15. Review
  16. Article
  17. Mechanisms of the NADFrontiers in cell and developmental biology · 2024
    Review
  18. Advances in mesenchymal stem cells therapy for tendinopathies.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Guanghao Wu *School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China.
Qihang Su *Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Jie Li *Department of Orthopedics, Zhabei Central Hospital of Jing'an District, Shanghai, 200070, China.
Chao XueDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Jie ZhuNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Qiuchen CaiDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Jingbiao HuangDepartment of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Shaoyang JiNational Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China. jishaoyang@ipe.ac.cn.
Biao ChengDepartment of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. dr_chengbiao@163.com.
Hengan GeDepartment of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. ghahayeah@163.com.
Shanghai Tenth People's Hospital · CNTongji University · CNInstitute of Process Engineering · CNBeijing Institute of Technology · CNShanghai Zhabei District Shibei Hospital · CN

Funding

National Natural Science Foundation of China Grant No.81972444, Grant No.81972095Project of Shanghai Health Commission Grant No.20194Y0385Project of Shanghai Science and Technology Commission Grant No.20S31901400, Grant No.19441901700, Grant No.19441901701, Grant No.19441901702
6 · The paper itself

Abstract

backgroundTendinopathy is the leading sports-related injury and will cause severe weakness and tenderness. Effective therapy for tendinopathy remains limited, and extracellular vesicles (EVs) derived from adipose tissue-derived mesenchymal stem cells (ADMSCs) have demonstrated great potential in tendinopathy treatment; however, the influence of aging status on EV treatment has not been previously described.

resultsIn this study, it was found that ADMSCs derived from old mice (ADMSC

conclusionsThis study demonstrates an effective novel therapy for tendinopathy and uncovers the influence of donor age on curative effects by clarifying the detailed biological mechanism.

Indexed as

Extracellular VesiclesMesenchymal Stem CellsTendinopathyAnimalsCytokinesMiceNicotinamide PhosphoribosyltransferaseSirtuin 1CytokinesNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseSirtuin 1Adipose tissue-derived mesenchymal stem cellsExtracellular vesiclesMacrophageNAD+ metabolismTendinopathy

Identifiers

PMID36604715
PMCPMC9814467
OpenAlexW4313559623

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.