Evidence map›Paper›PMID 36609018›Full record

ReviewTrends in cognitive sciences2023

Matrescence: lifetime impact of motherhood on cognition and the brain.

Edwina R Orchard, Helena J V Rutherford, Avram J Holmes, Sharna D Jamadar

Erratum issuedAbstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Maternal Satisfaction with Perinatal Care and Breastfeeding at 6 Months Postpartum.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Edwina R OrchardYale Child Study Center, School of Medicine, Yale University, New Haven, CT, USA; Department of Psychology, Faculty of Arts and Sciences, Yale University, New Haven, CT, USA. Electronic address: edwina.orchard@yale.edu.
Helena J V RutherfordYale Child Study Center, School of Medicine, Yale University, New Haven, CT, USA.
Avram J HolmesDepartment of Psychology, Faculty of Arts and Sciences, Yale University, New Haven, CT, USA.
Sharna D JamadarTurner Institute of Brain and Mental Health & Monash Biomedical Imaging, Monash University, Melbourne, Australia.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Psychosocial and neurobiological stress and opioid use trajectories following pregnancyR01DA050636 · NIDA · YALE UNIVERSITY · PI RUTHERFORD, HELENA JV, YIP, SARAH · 2020 to 2024
$2.8M
Translating brain to behavior: The reward-stress dysregulation model of addicted parentingR21DA052620 · NIDA · YALE UNIVERSITY · PI RUTHERFORD, HELENA JV · 2022 to 2023
$461k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA050636NIDA NIH HHS R21 DA052620NIMH NIH HHS R01 MH120080
6 · The paper itself

Abstract

Profound environmental, hormonal, and neurobiological changes mark the transition to motherhood as a major biosocial life event. Despite the ubiquity of motherhood, the enduring impact of caregiving on cognition and the brain across the lifespan is not well characterized and represents a unique window of opportunity to investigate human neural and cognitive development. By integrating insights from the human and animal maternal brain literatures with theories of cognitive ageing, we outline a framework for understanding maternal neural and cognitive changes across the lifespan. We suggest that the increased cognitive load of motherhood provides an initial challenge during the peripartum period, requiring continuous adaptation; yet when these demands are sustained across the lifespan, they result in increased late-life cognitive reserve.

Indexed as

BrainCognitive AgingAgingAnimalsCognitionFemaleHumansagingcognitioncognitive reservematrescencemotherhoodneurodevelopment

Identifiers

PMID36609018
PMCPMC9957969

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.