Evidence map›Paper›PMID 36609775›Full record

ReviewJournal of endocrinological investigation2023

Type 3 autoimmune polyglandular syndrome (APS-3) or type 3 multiple autoimmune syndrome (MAS-3): an expanding galaxy.

C Betterle, J Furmaniak, C Sabbadin, C Scaroni, F Presotto

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  6. A Rare Autoimmune Quartet: Immune Thrombocytopenia in a Patient with Autoimmune Polyglandular Syndrome Type 3Turkish journal of haematology : official journal of Turkish Society of Haematology · 2026
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  20. The Putative Role ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

C BetterleEndocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy. corrado.betterle@unipd.it.ORCID http://orcid.org/0000-0002-8996-410X
J Furmaniak, Thornhill, Cardiff, UK.
C SabbadinEndocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
C ScaroniEndocrine Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
F PresottoUnit of Internal Medicine, Ospedale Dell'Angelo, Mestre-Venice, Italy.
University of Padua · ITOspedale dell' Angelo · ITThornhill Medical (Canada) · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe number of recognised distinct autoimmune diseases (AIDs) has progressively increased over the years with more than 100 being reported today. The natural history of AIDs is characterized by progression from latent and subclinical to clinical stages and is associated with the presence of the specific circulating autoantibodies. Once presented, AIDs are generally chronic conditions. AIDs have the tendency to cluster and co-occur in a single patient. Autoimmune thyroid diseases (AITD) are the most prevalent of AIDs in the world population, and about one-third of the AITD patients also present with a non-thyroid AID during their life-span. Furthermore, patient with non-thyroid AIDs often presents with a form of AITD as a concurrent condition. Many of the clusters of AIDs are well characterized as distinctive syndromes, while some are infrequent and only described in case reports. PURPOSE: In this review, we describe the wide spectrum of the combinations and the intricate relationships between AITD and the other AIDs, excluding Addison's disease. These combinations are collectively termed type 3 Autoimmune Polyglandular Syndrome (APS-3), also called type 3 Multiple Autoimmune Syndrome (MAS-3), and represent the most frequent APS in the world populations.

conclusionsNumerous associations of AITD with various AIDs could be viewed as if the other AIDs were gravitating like satellites around AITD located in the center of a progressively expanding galaxy of autoimmunity.

Indexed as

Addison DiseaseHashimoto DiseasePolyendocrinopathies, AutoimmuneAutoantibodiesHumansPropylaminesSilanesSyndrome3-aminopropyltrimethoxysilaneAutoantibodiesPropylaminesSilanesAutoimmune diseasesAutoimmune polyendocrine syndromesChronic thyroiditisGraves’ diseaseMultiple autoimmune syndromesPolyautoimmunityThyroid autoimmune diseases

Identifiers

PMID36609775
OpenAlexW4313642956

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.