Evidence map›Paper›PMID 36610939›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2023

The use of angiotensin system inhibitors correlates with longer survival in resected pancreatic adenocarcinoma patients.

Hao Liu, Ibrahim Nassour, Steven Lebowitz, Mark D'Alesio, Erica Hampton, Annissa Desilva, Abdulrahman Hammad, Samer AlMasri, Hussein H Khachfe, Aatur Singhi and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Pancreatic Cancer: A Review of Risk Factors.Life (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Hao LiuDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Ibrahim NassourDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Steven LebowitzSchool of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Mark D'AlesioSchool of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Erica HamptonSchool of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Annissa DesilvaDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Abdulrahman HammadDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Samer AlMasriDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Hussein H KhachfeDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Aatur SinghiDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Nathan BaharyDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Kenneth LeeDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Amer ZureikatDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Alessandro PanicciaDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. Electronic address: panicciaa2@upmc.edu.
University of Pittsburgh Medical Center · USUniversity of Pittsburgh · USUPMC Health System · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

backgroundActivities and inhibition of the Renin-Angiotensin-Aldosterone System (RAAS) may affect the survival of resected pancreatic ductal adenocarcinoma (PDAC) patients

methodA single-institution retrospective analysis of resected PDAC patients between 2010 and 2019. To estimate the effect of angiotensin system inhibitors (ASIs) on patient survival, we performed Kaplan Meier analysis, Cox Proportional Hazards model, Propensity Score Matching (PSM), and inverse probability weighting (IPW) analysis.

results742 patients were included in the analysis. The average age was 67.0 years, with a median follow-up of 24.1 months. The use of ASI was associated with significantly longer overall survival in univariate (p = 0.004) and multivariable (HR = 0.70 [0.56-0.88],p = 0.003) adjusted analysis. In a propensity score-matched cohort of 400 patients, ASI use was again associated with longer overall survival (p = 0.039). Lastly, inverse probability weighting (IPW) analysis suggested that the use of ASI was associated with an average treatment effect on the treated (ATT) of HR = 0.68 [0.53-0.86],p = 0.002) for overall survival.

conclusionIn this single-institution retrospective study focusing on resected PDAC patients, the use of ASI was associated with longer overall survival in multiple statistical models. Prospective clinical trials are needed before routine clinical implementation of ASI as an adjuvant to existing therapy can be recommended.

Indexed as

AdenocarcinomaCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAgedAngiotensinsHumansProspective StudiesRetrospective StudiesAngiotensinsangiotensin system inhibitorspancreatic cancerPDACRenin-Angiotensin-Aldosterone System

Identifiers

PMID36610939
PMCPMC11199074
OpenAlexW4311302211

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.