Evidence map›Paper›PMID 36611941›Full record

ArticleCells2022

Arf-like Protein 2 (ARL2) Controls Microtubule Neogenesis during Early Postnatal Photoreceptor Development.

Cecilia D Gerstner, Michelle Reed, Tiffanie M Dahl, Guoxin Ying, Jeanne M Frederick, Wolfgang Baehr

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cecilia D GerstnerDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
Michelle ReedDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
Tiffanie M DahlDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
Guoxin YingDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
Jeanne M FrederickDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.ORCID 0000-0002-8693-057X
Wolfgang BaehrDepartment of Ophthalmology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
University of Utah · US

Funding

University of Utah, Core Vision Research GrantP30EY014800 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jun Yang · 2005 to 2026
$14.6M
RETINAL PHOTORECEPTOR CYCLIC GMP PHOSPHODIESTERASER01EY008123 · NEI · UNIVERSITY OF UTAH · PI BAEHR, WOLFGANG · 1990 to 2019
$7.8M
Membrane Protein Transport in PhotoreceptorsR01EY019298 · NEI · UNIVERSITY OF UTAH · PI BAEHR, WOLFGANG · 2009 to 2018
$3.7M
Vision Research Training Grant at the University of UtahT32EY024234 · NEI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI DAVID KRIZAJ, Monica L Vetter · 2014 to 2026
$2.3M
NEI NIH HHS 5T32 EY024234NEI NIH HHS EY014800-039003NEI NIH HHS EY019298NEI NIH HHS EY08123NEI NIH HHS P30 EY014800NEI NIH HHS T32 EY024234
6 · The paper itself

Abstract

Arf-like protein 2 (ARL2) is a ubiquitously expressed small GTPase with multiple functions. In a cell culture, ARL2 participates with tubulin cofactor D (TBCD) in the neogenesis of tubulin αβ-heterodimers, the building blocks of microtubules. To evaluate this function in the retina, we conditionally deleted ARL2 in mouse retina at two distinct stages, either during the embryonic development (

Indexed as

DyneinsTubulinAnimalsMiceMicrotubulesPhotoreceptor CellsRetinaDyneinsTubulinArf-like protein 2 (ARL2)dynein heavy chain (DYNC1H1)microtubule cytoskeleton (MTC)retinarod photoreceptorstubulin αβ-heterodimers

Identifiers

PMID36611941
PMCPMC9818799
OpenAlexW4313361057

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.