Evidence map›Paper›PMID 36613483›Full record

ArticleInternational journal of molecular sciences2022

Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with Renal and Cardiovascular Damage in Chronic Kidney Disease.

Francisco Javier Manzano-Lista, Marta Sanz-Gómez, Daniel González-Moreno, Elena Vega-Martín, Marta Gil-Ortega, Angela Schulz, Miguel Ángel Rubio, Gema Ruiz-Hurtado, Luis Miguel Ruilope, Isabel Aránguez and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Francisco Javier Manzano-ListaInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Marta Sanz-GómezInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-2251-5876
Daniel González-MorenoInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Elena Vega-MartínInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Marta Gil-OrtegaDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad CEU-San Pablo, 28925 Madrid, Spain.ORCID 0000-0002-6366-8214
Angela SchulzDepartment of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin, 10117 Berlin, Germany.ORCID 0000-0002-4576-8035
Miguel Ángel RubioServicio de Endocrinología y Nutrición, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Gema Ruiz-HurtadoUnidad de Hipertensión, Instituto de Investigación Imas12, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0003-3482-0915
Luis Miguel RuilopeUnidad de Hipertensión, Instituto de Investigación Imas12, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
Isabel AránguezInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Reinhold KreutzDepartment of Clinical Pharmacology and Toxicology, Charité-Universitätsmedizin, 10117 Berlin, Germany.
María S Fernández-AlfonsoInstituto Pluridisciplinar, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-9110-8070
Universidad Complutense de Madrid · ESCharité - Universitätsmedizin Berlin · DEHospital Universitario 12 De Octubre · ESUniversidad San Pablo CEU · ESHospital Clínico San Carlos · ES

Funding

Ministerio de Economía y Competitividad BFU2017-82565-C2-2-R
6 · The paper itself

Abstract

Arterial stiffness is a major vascular complication of chronic kidney disease (CKD). The development of renal damage, hypertension, and increased pulse wave velocity (PWV) in CKD might be associated with an imbalance in bone morphogenetic proteins (BMP)-2 and BMP-7. Plasma BMP-2 and BMP-7 were determined by ELISA in CKD patients (stages I-III; n = 95) and Munich Wistar Frömter (MWF) rats. Age-matched Wistar rats were used as a control. The expression of

Indexed as

Renal Insufficiency, ChronicVascular StiffnessAnimalsBone Morphogenetic Protein 2Bone Morphogenetic Protein 7KidneyPulse Wave AnalysisRatsRats, WistarBmp2 protein, ratBmp7 protein, ratBone Morphogenetic Protein 2Bone Morphogenetic Protein 7arterial stiffnessbone morphogenetic proteinscardiovascular diseasechronic kidney diseaseMunich Wistar Frömter Rat

Identifiers

PMID36613483
PMCPMC9820638
OpenAlexW4313503353

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.