Evidence map›Paper›PMID 36613611›Full record

ArticleInternational journal of molecular sciences2022

CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene

Chiara Gabellini, Cecilia Pucci, Chiara De Cesari, Davide Martini, Caterina Di Lauro, Matteo Digregorio, William Norton, Alessio Zippo, Alessandro Sessa, Vania Broccoli and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Chiara GabelliniUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.ORCID 0000-0002-5544-1570
Cecilia PucciUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.
Chiara De CesariUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.
Davide MartiniUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.
Caterina Di LauroUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.
Matteo DigregorioUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.
William NortonDepartment of Genetics and Genome Biology, University of Leicester, Leicester LE1 7RH, UK.
Alessio ZippoLaboratory of Chromatin Biology & Epigenetics, Center for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.ORCID 0000-0002-3686-6151
Alessandro SessaStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-3611-5056
Vania BroccoliStem Cell and Neurogenesis Unit, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milan, Italy.ORCID 0000-0003-4050-0926
Massimiliano AndreazzoliUnit of Cell and Developmental Biology, Department of Biology, University of Pisa, 56123 Pisa, Italy.ORCID 0000-0001-9633-204X
University of Pisa · ITVita-Salute San Raffaele University · ITUniversity of Leicester · GBUniversity of Trento · IT

Funding

Italian Ministry of University and Research PRIN2017 #2017M95WBATelethon Foundation GGP15096B
6 · The paper itself

Abstract

Haploinsufficiency of the

Indexed as

Autism Spectrum DisorderMethyltransferasesAnimalsBrainCRISPR-Cas SystemsHumansSocial BehaviorZebrafishZebrafish ProteinsMethyltransferasesSetd5 protein, zebrafishZebrafish Proteinsautismbehaviorneurodevelopmentsetd5zebrafish

Identifiers

PMID36613611
PMCPMC9820161
OpenAlexW2899559949

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.