Evidence map›Paper›PMID 36613635›Full record

ArticleInternational journal of molecular sciences2022

Intronic Enhancer Is Essential for

Yuichi Shima, Kanako Miyabayashi, Takami Mori, Koji Ono, Mizuki Kajimoto, Hae Lim Cho, Hitomi Tsuchida, Yoshihisa Uenoyama, Hiroko Tsukamura, Kentaro Suzuki and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. A Novel Variant inJCEM case reports · 2025
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Yuichi ShimaDivision of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Fukuoka, Japan.
Kanako MiyabayashiDivision of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Fukuoka, Japan.
Takami MoriDepartment of Medical Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki 701-0193, Okayama, Japan.
Koji OnoDepartment of Anatomy, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Okayama, Japan.ORCID 0000-0001-5627-026X
Mizuki KajimotoPharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd. (SNBL), 16-1 Minamiakasaka, Kainan-shi 642-0017, Wakayama, Japan.
Hae Lim ChoCenter for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seoul 02792, Republic of Korea.
Hitomi TsuchidaLaboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Aichi, Japan.
Yoshihisa UenoyamaLaboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Aichi, Japan.ORCID 0000-0002-8272-2781
Hiroko TsukamuraLaboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Aichi, Japan.
Kentaro SuzukiFaculty of Life and Environmental Sciences, University of Yamanashi, 4-4-37, Takeda, Kofu 400-8510, Yamanashi, Japan.
Man Ho ChoiCenter for Advanced Biomolecular Recognition, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seoul 02792, Republic of Korea.
Kazunori ToidaDepartment of Anatomy, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Okayama, Japan.
Nagoya University · JPKawasaki Medical School · JPKorea Institute of Science and Technology · KRKurume University · JPKawasaki University of Medical Welfare · JPShin Nippon Biomedical Laboratories (Japan) · JPTakeda (Japan) · JP

Funding

Japan Society for the Promotion of Science 21H00235Research Project Grant from Kawasaki Medical School R02B-025
6 · The paper itself

Abstract

Nuclear receptor subfamily 5 group A member 1 (NR5A1) is expressed in the pituitary gonadotrope and regulates their differentiation. Although several regulatory regions were implicated in

Indexed as

GonadotrophsPituitary GlandRegulatory Sequences, Nucleic AcidSteroidogenic Factor 1AnimalsIntronsMaleMiceSteroidogenic Factor 1steroidogenic factor 1, mouseenhancerfollicle-stimulating hormoneluteinizing hormoneNR5A1pituitary gonadotrope

Identifiers

PMID36613635
PMCPMC9820228
OpenAlexW4313577899

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.