Evidence map›Paper›PMID 36613790›Full record

ArticleInternational journal of molecular sciences2022

Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia.

Yawen Hu, Rebecca A Hill, Masami Yoshimura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yawen HuDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine Louisiana State University, Baton Rouge, LA 70803, USA.
Rebecca A HillDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine Louisiana State University, Baton Rouge, LA 70803, USA.
Masami YoshimuraDepartment of Comparative Biomedical Sciences, School of Veterinary Medicine Louisiana State University, Baton Rouge, LA 70803, USA.ORCID 0000-0001-9955-3702
Louisiana State University · US

Funding

Role of AC7 and alcohol in innate immune responses during bacterial infectionR03AA029165 · NIAAA · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI YOSHIMURA, MASAMI · 2021 to 2022
$145k
NIAAA NIH HHS R03 AA029165NIH HHS AA029165
6 · The paper itself

Abstract

To assess the role of adenylyl cyclase type 7 (AC7) in microglia's immune function, we generated AC7 gene knockout (AC7 KO) clones from a mouse microglial cell line, BV-2, using the CRISPR-Cas9 gene editing system. The ability of BV-2 cells to generate cAMP and their innate immune functions were examined in the presence or absence of ethanol. The parental BV-2 cells showed robust cAMP production when stimulated with prostaglandin-E

Indexed as

Adenylyl CyclasesMicrogliaAlprostadilAnimalsCell LineEthanolMiceadenylyl cyclase 7Adenylyl CyclasesAlprostadilEthanoladenylyl cyclase type 7alcoholCRISPR-Cas9 gene editingmacrophage activationmicroglia

Identifiers

PMID36613790
PMCPMC9820266
OpenAlexW4313260538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.