Evidence mapPaperPMID 36613916Full record

ArticleInternational journal of molecular sciences2022

Bempedoic Acid Restores Liver H

Núria Roglans, Elena Fauste, Roger Bentanachs, Ana M Velázquez, Madelin Pérez-Armas, Cristina Donis, María I Panadero, Marta Alegret, Paola Otero, Carlos Bocos and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  6. Article
  7. NAFLD/MAFLD: New Evidence.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Núria RoglansDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.ORCID 0000-0002-5018-021X
Elena FausteFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.ORCID 0000-0002-5783-3092
Roger BentanachsDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.ORCID 0000-0002-9714-163X
Ana M VelázquezDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.
Madelin Pérez-ArmasFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.
Cristina DonisFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.ORCID 0000-0003-2558-9539
María I PanaderoFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.ORCID 0000-0003-0459-3539
Marta AlegretDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.ORCID 0000-0002-5652-8651
Paola OteroFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.ORCID 0000-0001-5107-6185
Carlos BocosFacultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Montepríncipe, Boadilla del Monte, 28668 Madrid, Spain.ORCID 0000-0003-0364-5958
Juan C LagunaDepartment of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.ORCID 0000-0002-7082-0704
Universidad San Pablo CEU · ESInstituto de Salud Carlos III · ESInstitute for Research in Biomedicine · ES

Funding

Generalitat de Catalunya 2017SGR38Ministerio de Ciencia e Innovación España PID2020-112870RB-I00Ministerio de Ciencia e Innovación España PID2020-118054RB-I00
6 · The paper itself

Abstract

We previously demonstrated that treatment with BemA (bempedoic acid), an inhibitor of ATP citrate lyase, significantly reduces fatty liver in a model of liver steatosis (HFHFr-female Sprague-Dawley rat fed a high-fat high-fructose diet). Since the hepatic production of the gasotransmitter H

Indexed as

Hydrogen SulfideNon-alcoholic Fatty Liver DiseaseAnimalsCystathionine beta-SynthaseCystathionine gamma-LyaseDicarboxylic AcidsDiet, High-FatFatty AcidsFemaleRatsRats, Sprague-Dawley8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acidCystathionine beta-SynthaseCystathionine gamma-LyaseDicarboxylic AcidsFatty AcidsHydrogen SulfidefructoseFXRhigh-fat dietmTORC1NAFLDPGC1αS6K1

Identifiers

PMID36613916
PMCPMC9820553
OpenAlexW4313414193

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.