Evidence map›Paper›PMID 36614194›Full record

ArticleInternational journal of molecular sciences2023

Target-Specific Nanoparticle Polyplex Down-Regulates Mutant

Jill P Smith, Wenqiang Chen, Narayan Shivapurkar, Monica Gerber, Robin D Tucker, Bhaskar Kallakury, Siva Sai Krishna Dasa, Ruvanthi N Kularatne, Stephan T Stern

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jill P SmithDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0002-0835-4802
Wenqiang ChenDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.
Narayan ShivapurkarDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.
Monica GerberDepartment of Medicine, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0001-5855-2535
Robin D TuckerDepartment of Pathology, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0003-0081-4752
Bhaskar KallakuryDepartment of Pathology, Georgetown University, Washington, DC 20007, USA.
Siva Sai Krishna DasaNanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.
Ruvanthi N KularatneNanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.
Stephan T SternNanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.ORCID 0000-0003-1150-7598
Georgetown University · USFrederick National Laboratory for Cancer Research · US

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
American Association For Cancer Research 21-80-44-SMITDon Harrington Discovery Center HDI2021-SI-6164NCI NIH HHS 75N91019D00024NCI NIH HHS P30 CA051008NCI NIH HHS P30-CA051008NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Survival from pancreatic cancer is poor because most cancers are diagnosed in the late stages and there are no therapies to prevent the progression of precancerous pancreatic intraepithelial neoplasms (PanINs). Inhibiting mutant

Indexed as

Carcinoma in SituCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCarcinogenesisDisease Models, AnimalHumansMicePancreasProto-Oncogene Proteins p21(ras)KRAS protein, humanProto-Oncogene Proteins p21(ras)cholecystokinin receptormutant Krasnanoparticlespancreatic cancer

Identifiers

PMID36614194
PMCPMC9821664
OpenAlexW4313473181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.