Evidence map›Paper›PMID 36614308›Full record

ReviewInternational journal of molecular sciences2023

Inflammation in Urological Malignancies: The Silent Killer.

Martina Catalano, Giandomenico Roviello, Raffaella Santi, Donata Villari, Pietro Spatafora, Ilaria Camilla Galli, Francesco Sessa, Francesco Lupo Conte, Enrico Mini, Tommaso Cai and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  6. Association ofInternational journal of molecular sciences · 2026
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  14. Inflammation in Penile Squamous Cell Carcinoma: A Comprehensive Review.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Martina CatalanoSchool of Human Health Sciences, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-1856-2848
Giandomenico RovielloSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Raffaella SantiSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.
Donata VillariDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Pietro SpataforaUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Teaching Hospital, 50134 Florence, Italy.
Ilaria Camilla GalliHistopathology and Molecular Diagnostics, Careggi Teaching Hospital, 50139 Florence, Italy.
Francesco SessaUnit of Urological Robotic Surgery and Renal Transplantation, Careggi Teaching Hospital, 50134 Florence, Italy.
Francesco Lupo ConteSchool of Human Health Sciences, University of Florence, 50134 Florence, Italy.
Enrico MiniSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-1853-8557
Tommaso CaiDepartment of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy.ORCID 0000-0002-7234-3526
Gabriella NesiSection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, Italy.ORCID 0000-0002-2614-944X
University of Florence · ITAzienda Ospedaliero-Universitaria Careggi · ITOspedale Santa Chiara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have investigated the role of inflammation in promoting tumorigenesis and cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to establish an inflammatory tumor microenvironment. The tumor-associated inflammatory tissue is highly plastic, capable of continuously modifying its phenotypic and functional characteristics. Accumulating evidence suggests that chronic inflammation plays a critical role in the development of urological cancers. Here, we review the origins of inflammation in urothelial, prostatic, renal, testicular, and penile cancers, focusing on the mechanisms that drive tumor initiation, growth, progression, and metastasis. We also discuss how tumor-associated inflammatory tissue may be a diagnostic marker of clinically significant tumor progression risk and the target for future anti-cancer therapies.

Indexed as

Penile NeoplasmsUrologic NeoplasmsCarcinogenesisCell Transformation, NeoplasticHumansInflammationMaleTumor Microenvironmentcancergenitourinary tumorsinflammationtumorigenesis

Identifiers

PMID36614308
PMCPMC9821648
OpenAlexW4313466503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.