Evidence mapPaperPMID 36615489Full record

ArticleMolecules (Basel, Switzerland)2022

Enhanced Anti-Inflammatory Effect of the Combination of

Katarína Pružinská, Lukáš Slovák, František Dráfi, Silvester Poništ, Ivo Juránek, Martin Chrastina, Karol Švík, Ladislav Strojný, Ľuboš Ambro, Katarína Bauerová

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Therapeutic potential of the probioticCurrent research in food science · 2024
    Article
  7. Nutrients · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katarína PružinskáCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
Lukáš SlovákCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
František DráfiCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.ORCID 0000-0001-9287-5514
Silvester PoništCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
Ivo JuránekCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
Martin ChrastinaCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
Karol ŠvíkCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.
Ladislav StrojnýCenter of Clinical and Preclinical Research, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 04011 Košice, Slovakia.
Ľuboš AmbroCenter for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik University, Jesenná 5, 04001 Košice, Slovakia.
Katarína BauerováCentre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia.ORCID 0000-0002-7863-2142
Slovak Academy of Sciences · SKUniversity of Pavol Jozef Šafárik · SK

Funding

Slovak Research and Development Agency 15-0308VEGA (Slovakia) 2/0136/20
6 · The paper itself

Abstract

The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is one of the therapeutic benefits of probiotics. The aim of the current investigation was to determine the impact of MTX therapy combined with one of the Lactobacillus strains,

Indexed as

Antirheumatic AgentsArthritis, ExperimentalArthritis, RheumatoidAnimalsAnti-Inflammatory AgentsDrug Therapy, CombinationMethotrexateRatsAnti-Inflammatory AgentsAntirheumatic AgentsMethotrexateadjuvant arthritisimmune modulationinflammationLactiplantibacillus plantarum LS/07Lactobacillimethotrexateprobiotics

Identifiers

PMID36615489
PMCPMC9822002
OpenAlexW4313294720

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.