Trial reportNutrients2022
Postprandial Metabolic and Oxidative Stress Responses to Grape Pomace Extract in Healthy Normal and Overweight/Obese Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.
Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Characterization of theMolecules (Basel, Switzerland) · 2024Trial
- The Oxidative Stress: Origin and Role in Aging and Diseases.Antioxidants (Basel, Switzerland) · 2026Review
- Bioprocessing of Grape Pomace for Value Added Ingredients with Utilization in Baked Products.Foods (Basel, Switzerland) · 2025Review
- Enhancing Human Health Through Nutrient and Bioactive Compound Recovery from Agri-Food By-Products: A Decade of Progress.Nutrients · 2025Review
- From meal to malfunction: exploring molecular pathways, biomarkers and interventions in postprandial cardiometabolic health.Frontiers in cardiovascular medicine · 2025Review
- The high-value and sustainable utilization of grape pomace: A review.Food chemistry: X · 2024Review
- Health-Promoting Properties and the Use of Fruit Pomace in the Food Industry-A Review.Nutrients · 2024Review
- Effect of oleocanthal-rich olive oil on postprandial oxidative stress markers of patients with type 2 diabetes mellitus.Food & nutrition research · 2024Article
- A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study.Frontiers in nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Postprandial oxidative stress has been shown to promote atherosclerosis. Grape pomace (GP) is a source of similar-to-wine bioactive micro-constituents with known antioxidant properties. The aim of the present study was to evaluate metabolic and oxidative stress responses after the intake of grape pomace (GP) extract along with a high-fat meal, in normal and overweight healthy women. In a randomized, double-blind, placebo-controlled crossover study, 18 women were finally included, 11 with BMI < 25 kg/m2 and 7 with BMI > 25 kg/m2, and consumed a high-fat meal with placebo or GP extract capsules in two separate visits. Blood samples were collected before and 6 h after the consumption. Measurements included basic biochemical markers, uric acid (UA), protein carbonyls (PC), thiobarbituric acid substance (TBARS) levels, as well as superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. At certain time points, the GP extract consumption in normal-weight women reduced UA, TBARS levels, and SOD activity, whereas it increased UA and reduced PC levels in overweight/obese women, compared to the placebo. GP-derived bioactive compounds may exert antioxidant actions during the postprandial state in healthy women, through different mechanisms according to their BMI status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.