Evidence map›Paper›PMID 36615902›Full record

ArticleNutrients2023

Perinatal Fat-Diets Increased Angiotensin II-Mediated Ca

Qiutong Zheng, Yun He, Lingjun Li, Can Rui, Na Li, Yumeng Zhang, Yang Ye, Ze Zhang, Xiaojun Yang, Jiaqi Tang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Qiutong ZhengInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Yun HeInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Lingjun LiInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Can RuiNanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing 210004, China.
Na LiMaternal and Child Health Care Hospital of Wuxi, Jiangnan University, Wuxi 214122, China.
Yumeng ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Yang YeMaternal and Child Health Care Hospital of Wuxi, Jiangnan University, Wuxi 214122, China.
Ze ZhangInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Xiaojun YangInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Jiaqi TangInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.
Zhice XuInstitute for Fetology, First Hospital of Soochow University, Suzhou 215006, China.ORCID 0000-0002-6319-0206
Soochow University · CNJiangnan University · CNNanjing Maternity and Child Health Care Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perinatal malnutrition affects vascular functions, and calcium is important in vascular regulations. It is unknown whether and how perinatal maternal high-fat diets (MHF)-mediated vascular dysfunction occurs via the angiotensin-PKC-L-type-calcium-channels (LTCC) axis. This study determined angiotensin II (AII) roles in the PKC-LTCC axis in controlling calcium influx in the arteries of offspring after perinatal MHF. Mesenteric arteries (MA) and smooth muscle cells (SMCs) from 5-month-old offspring rats were studied using physiological, ion channel, molecular, and epigenetic analysis. Pressor responses to AII were significantly increased in the free-moving MHF offspring rats. In cell experiments, MA-SMC proliferation was enhanced, and associated with thicker vascular wall in the obese offspring. Imaging analysis showed increase of fluorescence Ca

Indexed as

Angiotensin IICalcium Channels, L-TypeAnimalsCalciumDietDNA MethylationFemaleMesenteric ArteriesPregnancyRatsReceptor, Angiotensin, Type 1Agtr1a protein, ratAngiotensin IICalciumCalcium Channels, L-TypeReceptor, Angiotensin, Type 1DNA methylationL-type-calcium-channelperinatal high-fat-dietsPKC

Identifiers

PMID36615902
PMCPMC9824013
OpenAlexW4313584862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.