ReviewFrontiers in veterinary science2022
Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming.
Review in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Developmental programming in dogs.Biology of reproduction · 2026Review
- A placebo-controlled study of the effects of Saccharomyces cerevisiae var. boulardii CNCM I-1079 probiotic on faecal quality, microbiota and immunity in weaned kittens.Animal microbiome · 2026Article
- Neonatal Gut Microbiota in Puppies and Kittens: From Maternal Transmission to Immune Development.Animals : an open access journal from MDPI · 2026Review
- Gonadectomy and Its Association with Orthopedic and Neoplastic Disorders: A Retrospective Study in Belgium-Part I (Bitches).Life (Basel, Switzerland) · 2026Article
- Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024.BMC veterinary research · 2026Article
- The perinatal microbiota in dogs and cats: a narrative review from human research to veterinary practice.Frontiers in veterinary science · 2026Review
- Feeding practices, purchasing behaviors, and their association with non-communicable diseases in dogs: Insights from Thai pet owners.Veterinary world · 2025Article
- Environmental exposures and health outcomes in dogs differ according to geographic region in the United States among Dog Aging Project participants.American journal of veterinary research · 2025Article
- A Review of Probiotic Supplementation and Its Impact on the Health and Well-Being of Domestic Cats.Veterinary sciences · 2025Review
- Dynamic development of gut microbiota and metabolism during and after weaning of kittens.Animal microbiome · 2025Article
- Food supplemented with a novel fiber blend containing soluble and insoluble fiber supported growth and fecal parameters indicative of gastrointestinal health in kittens.Journal of animal science · 2025Article
- The Welfare of Dogs and Cats in the European Union: A Gap Analysis of the Current Legal Framework.Animals : an open access journal from MDPI · 2024Article
- Effects of Lactoferrin andAnimals : an open access journal from MDPI · 2024Article
- Prioritization of Appearance over Health and Temperament Is Detrimental to the Welfare of Purebred Dogs and Cats.Animals : an open access journal from MDPI · 2024Article
- Identifying the target population and preventive strategies to combat feline obesity.Journal of feline medicine and surgery · 2024Review
- Impact of compensatory growth on survival in newborn kittens.Frontiers in veterinary science · 2024Article
- Roles of Nutrients in the Brain Development, Cognitive Function, and Mood of Dogs and Cats.Advances in experimental medicine and biology · 2024Article
- The supplementation of female dogs with live yeastFrontiers in nutrition · 2024Article
- Relative Impact of Birth Weight and Early Growth on Neonatal Mortality in Puppies.Animals : an open access journal from MDPI · 2023Article
- Association between Birth Weight and Mortality over the Two First Months after Birth in Feline Species: Definition of Breed-Specific Thresholds.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many dogs and cats are affected by chronic diseases that significantly impact their health and welfare and relationships with humans. Some of these diseases can be challenging to treat, and a better understanding of early-life risk factors for diseases occurring in adulthood is key to improving preventive veterinary care and husbandry practices. This article reviews early-life risk factors for obesity and chronic enteropathy, and for chronic behavioral problems, which can also be intractable with life-changing consequences. Aspects of early life in puppies and kittens that can impact the risk of adult disorders include maternal nutrition, establishment of the gut microbiome, maternal behavior, weaning, nutrition during growth, growth rate, socialization with conspecifics and humans, rehoming and neutering. Despite evidence in some species that the disorders reviewed here reflect the developmental origins of health and disease (DOHaD), developmental programming has rarely been studied in dogs and cats. Priorities and strategies to increase knowledge of early-life risk factors and DOHaD in dogs and cats are discussed. Critical windows of development are proposed: preconception, gestation, the suckling period, early growth pre-neutering or pre-puberty, and growth post-neutering or post-puberty to adult size, the durations of which depend upon species and breed. Challenges to DOHaD research in these species include a large number of breeds with wide genetic and phenotypic variability, and the existence of many mixed-breed individuals. Moreover, difficulties in conducting prospective lifelong cohort studies are exacerbated by discontinuity in pet husbandry between breeders and subsequent owners, and by the dispersed nature of pet ownership.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.