ReviewPsychological medicine2023
Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance.
Review in Psychological medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of non-pharmacological interventions for older adults with dementia: An umbrella review.International journal of nursing sciences · 2026Pooled it
- Effects of monoclonal antibody therapies on depression in Parkinson's disease and Alzheimer's disease: Systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Management of Anxiety in Parkinson's Disease.Movement disorders clinical practice · 2025Pooled it
- Trial
- Adapted problem adaptation therapy for depression in mild to moderate Alzheimer's disease dementia: A randomized controlled trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- Depression in neurodegenerative disease: neurobiological mechanisms and emerging treatments.Molecular psychiatry · 2026Review
- Antidepressant use at the threshold: people prescribed antidepressants around the time of a dementia diagnosis.Age and ageing · 2026Article
- Antidepressant Use Among US Nursing Home Residents With Dementia.Journal of the American Geriatrics Society · 2026Article
- Characterizing treatment initiation with central nervous system-active polypharmacy among adults with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A dynamic risk prediction framework for Alzheimer's disease and related dementias with interpretability.NPJ digital medicine · 2026Article
- Neuropsychiatric Features in Patients With Idiopathic Normal Pressure Hydrocephalus: A Systematic Review and Meta-Analysis.Neurology. Clinical practice · 2026Review
- Cognitive Impairment, Dementia and Depression in Older Adults.Journal of clinical medicine · 2026Review
- Late-life difficult-to-treat depression and dementia subtypes: a naturalistic cohort study using electronic health records.Frontiers in psychiatry · 2026Article
- Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy,Journal of geriatric psychiatry and neurology · 2025Article
- A Self-Explainable Dynamic Risk Monitoring Framework for Predicting Alzheimer's Disease and Related Dementias.medRxiv : the preprint server for health sciences · 2025Article
- Catecholaminergic nucleus integrity and Alzheimer's pathology, symptoms, and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Alzheimer's Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective.International journal of molecular sciences · 2025Review
- Impaired reward sensitivity in Parkinson's depression is unresponsive to dopamine treatment.Brain : a journal of neurology · 2025Article
- Exploring the Impact of Cognitive Dysfunction During Recurrent Depression in a Sample of Mid-to-Older Age British South Asians: A Qualitative Study.Journal of psychiatric and mental health nursing · 2025Article
- Health outcomes in chronic kidney disease patients with cognitive impairment or dementia: a global collaborative analysis.Clinical kidney journal · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression in dementia is common, disabling and causes significant distress to patients and carers. Despite widespread use of antidepressants for depression in dementia, there is no evidence of therapeutic efficacy, and their use is potentially harmful in this patient group. Depression in dementia has poor outcomes and effective treatments are urgently needed. Understanding why antidepressants are ineffective in depression in dementia could provide insight into their mechanism of action and aid identification of new therapeutic targets. In this review we discuss why depression in dementia may be a distinct entity, current theories of how antidepressants work and how these mechanisms of action may be affected by disease processes in dementia. We also consider why clinicians continue to prescribe antidepressants in dementia, and novel approaches to understand and identify effective treatments for patients living with depression and dementia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.