Evidence map›Paper›PMID 36622633›Full record

ReviewInfectious diseases and therapy2023

Durability of Vaccine-Induced and Natural Immunity Against COVID-19: A Narrative Review.

Nick Pooley, Salim S Abdool Karim, Behazine Combadière, Eng Eong Ooi, Rebecca C Harris, Clotilde El Guerche Seblain, Masoumeh Kisomi, Nabila Shaikh

Open access · goldAbstract readReview
In one paragraph

Review in Infectious diseases and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
19.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Nick PooleyMaverex Ltd, The Old Forge, Hoults Yard, Newcastle-upon-Tyne, NE6 2HL, UK. nickpooley@maverex.com.
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa, Durban & Department of Epidemiology, Columbia University, New York, USA.
Behazine CombadièreInserm U1135, Sorbonne Université, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, 75013, Paris, France.
Eng Eong OoiProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore.
Rebecca C HarrisSanofi, 38 Beach Road 18-11, Singapore, 189767, Singapore.
Clotilde El Guerche SeblainSanofi, 14 Espace Henry Vallee, 19/23 Boulevard Jules Carteret, 69007, Lyon, France.
Masoumeh KisomiMaverex Ltd, The Old Forge, Hoults Yard, Newcastle-upon-Tyne, NE6 2HL, UK.
Nabila ShaikhSanofi, 410 Thames Valley Park Drive, Reading, RG6 1PT, Berkshire, UK.
Forge (United Kingdom) · GBCentre for the AIDS Programme of Research in South Africa · ZANational University Health System · SGSanofi (France) · FRSanofi (United Kingdom) · GBSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines developed against SARS-CoV-2 have proven to be highly effective in preventing symptomatic infection. Similarly, prior infection with SARS-CoV-2 has been shown to provide substantial protection against reinfection. However, it has become apparent that the protection provided to an individual after either vaccination or infection wanes over time. Waning protection is driven by both waning immunity over time since vaccination or initial infection, and the evolution of new variants of SARS-CoV-2. Both antibody and T/B-cells levels have been investigated as potential correlates of protection post-vaccination or post-infection. The activity of antibodies and T/B-cells provide some potential insight into the underlying causes of waning protection. This review seeks to summarise what is currently known about the waning of protection provided by both vaccination and/or prior infection, as well as the current information on the respective antibody and T/B-cell responses.

Indexed as

Antibody levelsBreakthrough infectionCellular immunityReinfectionSARS-CoV-2Waning immunity

Identifiers

PMID36622633
PMCPMC9828372
OpenAlexW4313857579

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.