SynthesisPediatric research2023
Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.
Synthesis in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Sex differences in the risk of bronchopulmonary dysplasia and pulmonary hypertension: a Bayesian meta-analysis.Pediatric research · 2025Pooled it
- Early prediction of moderate-to-severe BPD or death in preterm infants using minute-level respiratory monitoring and explainable machine learning.Pediatric research · 2026Article
- Validation of a web-based clinical tool for predicting the risk of bronchopulmonary dysplasia in extremely preterm infants: a retrospective cohort study.BMJ paediatrics open · 2026Article
- Tissue Doppler Imaging, Pulmonary Haemodynamics and Conventional Echocardiographic Indices for Early Bronchopulmonary Dysplasia Prediction in Preterm Infants: A Prospective Observational Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Machine learning-based prognostic modeling of early clinical outcomes in very low birth weight infants: insights from a nationwide cohort on delivery room resuscitation, prematurity-related complications, and mortality.BMC medical informatics and decision making · 2026Article
- Early prediction of bronchopulmonary dysplasia by urinary metabolomics: a case-control study.Thorax · 2026Observational
- BPD prediction model for very preterm infants integrating chest X-ray scores within 7 days: a retrospective case-control study.BMJ open · 2026Article
- Clinical characteristics and respiratory management of bronchopulmonary dysplasia in preterm infants: a retrospective case-control study.Frontiers in pediatrics · 2026Article
- Association of caffeine citrate plus vitamin A/D drops with bronchopulmonary dysplasia and respiratory outcomes in preterm infants born at <32 weeks' gestation: a 72-h landmark retrospective cohort study.Frontiers in pediatrics · 2026Article
- A Respiratory Intervention Intensity Index for Supplemental Oxygen Use at Postnatal Day 28 in Preterm Infants Using BWQS Regression: Incremental Stratification Beyond Gestational Age in a Single-Center Retrospective Cohort Study.Journal of multidisciplinary healthcare · 2026Article
- [Development of dynamic multi-time-point clinical prediction models for bronchopulmonary dysplasia in preterm infants with gestational age < 32 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Development and validation of machine learning models for predicting bronchopulmonary dysplasia risk in preterm neonates based on antenatal determinants: a retrospective cohort study.BMC pediatrics · 2025Article
- Development and external validation of a machine learning model to predict bronchopulmonary dysplasia using dynamic factors.Scientific reports · 2025Article
- Validation of the NICHD Bronchopulmonary Dysplasia Outcome Estimator 2022 in a Quaternary Canadian NICU-A Single-Center Observational Study.Journal of clinical medicine · 2025Article
- Maternal inflammatory biomarkers and neonatal characteristics as predictors of bronchopulmonary dysplasia in preterm infants: a retrospective cohort study.Frontiers in medicine · 2025Article
- A Comparison of the 2022 Versus 2011 National Institute of Child Health and Human Development Web-Based Risk Estimator for Bronchopulmonary Dysplasia.Journal of pediatrics. Clinical practice · 2024Article
- Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants.Physiological measurement · 2024Observational
- Optimizing Invasive Neonatal Respiratory Care: A Systematic Review of Invasive Neurally Adjusted Ventilatory Assist.Healthcare (Basel, Switzerland) · 2024Review
- Prediction of bronchopulmonary dysplasia in very preterm infants: competitive risk model nomogram.Frontiers in pediatrics · 2024Article
- A clinical informatics approach to bronchopulmonary dysplasia: current barriers and future possibilities.Frontiers in pediatrics · 2024Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models. Studies using predictors available before day 14 of life to predict BPD in very preterm infants were included. Two reviewers assessed 7628 studies for eligibility. Meta-analysis of externally validated models was followed by validation using 62,864 very preterm infants in England and Wales. A total of 64 studies using 53 prediction models were included totalling 274,407 infants (range 32-156,587/study). In all, 35 (55%) studies predated 2010; 39 (61%) were single-centre studies. A total of 97% of studies had a high risk of bias, especially in the analysis domain. Following meta-analysis of 22 BPD and 11 BPD/death composite externally validated models, Laughon's day one model was the most promising in predicting BPD and death (C-statistic 0.76 (95% CI 0.70-0.81) and good calibration). Six models were externally validated in our cohort with C-statistics between 0.70 and 0.90 but with poor calibration. Few BPD prediction models were developed with contemporary populations, underwent external validation, or had calibration and impact analyses. Contemporary, validated, and dynamic prediction models are needed for targeted preventative strategies. IMPACT: This review aims to provide a comprehensive assessment of all BPD prediction models developed to address the uncertainty of which model is sufficiently valid and generalisable for use in clinical practice and research. Published BPD prediction models are mostly outdated, single centre and lack external validation. Laughon's 2011 model is the most promising but more robust models, using contemporary data with external validation are needed to support better treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.